2008
Association of Sleep Apnea Severity and Obesity with Insulin Resistance, C-Reactive Protein, and Leptin Levels in Male Patients with Obstructive Sleep Apnea
Kapsimalis F, Varouchakis G, Manousaki A, Daskas S, Nikita D, Kryger M, Gourgoulianis K. Association of Sleep Apnea Severity and Obesity with Insulin Resistance, C-Reactive Protein, and Leptin Levels in Male Patients with Obstructive Sleep Apnea. Lung 2008, 186: 209-217. PMID: 18365276, DOI: 10.1007/s00408-008-9082-x.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea severityObstructive sleep apneaNon-OSA groupBody mass indexModerate OSAS groupCRP levelsInsulin resistanceApnea severityOSAS groupMale patientsLeptin levelsSleep apneaSevere obstructive sleep apnea syndromeHomeostasis model assessment methodSevere sleep apneaSevere OSAS groupSleep apnea syndromeC-reactive proteinTotal sleep timeNocturnal hypoxemiaApnea syndromeModel assessment methodHip ratioMass index
2003
Morbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity
SHEPERTYCKY M, AL‐BARRAK M, KRYGER M. Morbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity. Sleep And Biological Rhythms 2003, 1: 15-28. DOI: 10.1046/j.1446-9235.2003.00003.x.Peer-Reviewed Original ResearchObstructive sleep apnea syndromeSevere cardiovascular outcomesCongestive heart failureIschemic heart diseaseCardiovascular morbidityHeart failureCardiovascular outcomesPulmonary hypertensionSystemic hypertensionHeart diseaseCardiac arrhythmiasContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentOngoing population-based studyLarge ongoing trialsUntreated OSAS patientsIndependent risk factorDevelopment of hypertensionEpisodes of apneaSleep apnea syndromePopulation-based studyEffect of treatmentNocturnal hypoxemiaOSA patientsOSAS patients
1989
The effect of oxygen on respiration and sleep in patients with congestive heart failure.
Hanly P, Millar T, Steljes D, Baert R, Frais M, Kryger M. The effect of oxygen on respiration and sleep in patients with congestive heart failure. Annals Of Internal Medicine 1989, 111: 777-82. PMID: 2817624, DOI: 10.7326/0003-4819-111-10-777.Peer-Reviewed Original ResearchConceptsStable congestive heart failureCheyne-Stokes respirationCongestive heart failureHeart failureTotal sleep timeOxygen therapySleep timeStage 1 NREM sleepPlacebo-controlled crossover studyLow-flow oxygenNocturnal oxygen saturationNocturnal oxygen therapyOutpatient cardiology clinicApnea-hypopnea indexNumber of arousalsStage 1 sleepStage 2 sleepSlow-wave sleepHyperpneic phaseNocturnal hypoxemiaSleep hypoxemiaMale patientsNasal cannulaeCardiology clinicCrossover study
1986
Sleep in Restrictive Lung Disease
George C, Kryger M. Sleep in Restrictive Lung Disease. Sleep 1986, 10: 409-418. PMID: 3317724, DOI: 10.1093/sleep/10.5.409.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseLung diseaseNocturnal oxygenNocturnal desaturationMuscle weaknessLung disease patientsRestrictive lung diseaseFibrotic lung diseaseUse of drugsFurther hypoxemiaNocturnal hypoxemiaNasal CPAPNocturnal hypoventilationAcute alveolitisLong-term evaluationRestrictive diseaseOxygenation abnormalitiesDisease patientsKyphoscoliosis patientsDeformity changesSleep changesSleep architectureSleep structureNeuromuscular diseasePatients