1980
Chemical Control of Ventilation and Sleep Arterial Oxygen Desaturation in Patients with COPD1–3
Fleetham J, Mezon B, West P, Bradley C, Anthonisen N, Kryger M. Chemical Control of Ventilation and Sleep Arterial Oxygen Desaturation in Patients with COPD1–3. American Journal Of Respiratory And Critical Care Medicine 1980, 122: 583-9. PMID: 7436124, DOI: 10.1164/arrd.1980.122.4.583.Peer-Reviewed Original ResearchConceptsO2 saturationSleep desaturationVentilatory sensitivityRapid eye movement (REM) sleepNocturnal changesArterial oxygen desaturationLowest O2 saturationHypoxic ventilatory responseArterial O2 saturationEye movement sleepHypoxemic COPDNocturnal desaturationOxygen desaturationLung functionBlood gasesVentilatory responseMovement sleepVentilatory controlPatientsMaximal desaturationSleepDesaturationSleep stagesHypercapniaWakefulness
1978
Familial aspects of decreased hypoxic drive in endurance athletes
Scoggin C, Doekel R, Kryger M, Zwillich C, Weil J. Familial aspects of decreased hypoxic drive in endurance athletes. Journal Of Applied Physiology 1978, 44: 464-468. PMID: 632187, DOI: 10.1152/jappl.1978.44.3.464.Peer-Reviewed Original ResearchConceptsVentilatory responseEndurance athletesLong-distance runnersHypoxic ventilatory responseUnexplained respiratory failureFamilies of patientsHypercapnic responseRespiratory failureVentilatory responsivenessEndurance athleticsHealthy parentsShape parameter ANonathletic controlsHypoxic responseHypoxiaSimilar extentFamilial aspectsHypercapniaConsequence of conditioningAthletesRecent studiesFamilial influencesRunnersResponsePatients
1976
Clinical Semi-Starvation — Depression of Hypoxic Ventilatory Response
Doekel R, Zwillich C, Scoggin C, Kryger M, Weil J. Clinical Semi-Starvation — Depression of Hypoxic Ventilatory Response. New England Journal Of Medicine 1976, 295: 358-361. PMID: 819829, DOI: 10.1056/nejm197608122950703.Peer-Reviewed Original ResearchConceptsHypoxic ventilatory responseVentilatory responseHypercapnic ventilatory responseMetabolic rateRespiratory failureIntravenous fluidsDecreased metabolic rateCarbohydrate dietNormal subjectsCaloric restrictionDay 10HypercapniaSupplemental electrolytesResponse responseSubjectsResponseHypoxemiaDecreaseHypoxiaAlimentationEffect of Meperidine on Occlusion Pressure Responses to Hypercapnia and Hypoxia with and without External Inspiratory Resistance1–3
Kryger M, Yacoub O, Dosman J, Macklem P, Anthonisen N. Effect of Meperidine on Occlusion Pressure Responses to Hypercapnia and Hypoxia with and without External Inspiratory Resistance1–3. American Journal Of Respiratory And Critical Care Medicine 1976, 114: 333-40. PMID: 973724, DOI: 10.1164/arrd.1976.114.2.333.Peer-Reviewed Original ResearchConceptsInspiratory resistanceNormal subjectsOcclusion pressure responsesInspiratory motor outputEffect of meperidineOral meperidineVentilatory responseAcute increaseInspiratory effortClosed airwayMeperidineHypercapniaProgressive hypoxiaMotor outputMore depressionHypoxiaHypoxic responsePressure responseP0.1Combination of resistanceSubjectsResponseAirway
1975
Effect of inspiratory resistance on occlusion pressure in hypoxia and hypercapnia
Kryger M, Yacoub O, Anthonisen N. Effect of inspiratory resistance on occlusion pressure in hypoxia and hypercapnia. Respiratory Physiology & Neurobiology 1975, 24: 241-248. PMID: 1188196, DOI: 10.1016/0034-5687(75)90016-x.Peer-Reviewed Original Research