1989
Heart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea
Hanly P, George C, Millar T, Kryger M. Heart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea. CHEST Journal 1989, 95: 735-739. PMID: 2924602, DOI: 10.1378/chest.95.4.735.Peer-Reviewed Original ResearchConceptsVoluntary respiratory maneuversObstructive sleep apneaHR responseSleep apneaRespiratory maneuversMueller maneuverOxygen saturationVagal toneAbsence of hypoxemiaArterial oxygen saturationHeart rate responseObstructive apneaMouth pressureApneaHR changesMale subjectsRate responseBreath holdSimilar durationValsalvaSignificant differencesSignificant correlationOSASMajor determinantWakefulness
1985
Sleep and Control of Heart Rate
George C, Kryger M. Sleep and Control of Heart Rate. Clinics In Chest Medicine 1985, 6: 595-601. PMID: 3853478, DOI: 10.1016/s0272-5231(21)00397-x.Peer-Reviewed Original ResearchConceptsHeart rateTotal peripheral vascular resistanceSinus arrhythmiaExaggerated sinus arrhythmiaAutonomic nervous system activityPeripheral vascular resistanceTransient AV blockNormal hemoglobin concentrationAutonomic nervous activityNervous system activityHeart rate responseStages of sleepVascular resistanceBlood pressureVentricular functionCardiac outputAV blockRhythm disturbancesCarotid bodyLung inflationNervous activityREM sleepRespiratory arrhythmiaHemoglobin concentrationRespiratory rate