2019
The role of home sleep testing for evaluation of patients with excessive daytime sleepiness: focus on obstructive sleep apnea and narcolepsy
Rosenberg R, Hirshkowitz M, Rapoport DM, Kryger M. The role of home sleep testing for evaluation of patients with excessive daytime sleepiness: focus on obstructive sleep apnea and narcolepsy. Sleep Medicine 2019, 56: 80-89. PMID: 30803831, DOI: 10.1016/j.sleep.2019.01.014.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHome sleep apnea testingObstructive sleep apneaExcessive daytime sleepinessSleep disordersSleep apneaEvaluation of EDSLow cerebrospinal fluid (CSF) hypocretin (orexin) levelsCerebrospinal fluid hypocretin levelsEvaluation of patientsDifferential clinical characteristicsDiagnosis of narcolepsySleep apnea testingHome sleep testingClinical characteristicsExcessive daytimeHypocretin levelsSleep testingApnea testingConsensus guidelinesLaboratory polysomnographyNarcolepsy diagnosisDaytime sleepinessCommon complaintMedical conditionsSubstantial burden
2015
Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome
Knauert M, Naik S, Gillespie MB, Kryger M. Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome. World Journal Of Otorhinolaryngology - Head And Neck Surgery 2015, 1: 17-27. PMID: 29204536, PMCID: PMC5698527, DOI: 10.1016/j.wjorl.2015.08.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsObstructive sleep apnea syndromeSleep apnea syndromeUntreated obstructive sleep apnea syndromeApnea syndromeEffective therapyPoor patient acceptanceStart date restrictionLack of diagnosisSignificant economic burdenEnglish-language studiesExcessive daytimeSleep apneaPatient acceptanceCardiovascular diseaseClinical consequencesDate restrictionsEconomic burdenMetabolic diseasesPubMed databaseAbnormal physiologySyndromeTherapyLack of accessDiseaseTreatment
2002
Low body stores of iron and restless legs syndrome: a correctable cause of insomnia in adolescents and teenagers
Kryger MH, Otake K, Foerster J. Low body stores of iron and restless legs syndrome: a correctable cause of insomnia in adolescents and teenagers. Sleep Medicine 2002, 3: 127-132. PMID: 14592231, DOI: 10.1016/s1389-9457(01)00160-5.Peer-Reviewed Original ResearchRestless legs syndromePercent iron saturationIron storesSubjective sleep latencyFerritin levelsLegs syndromeSleep latencySymptoms of RLSBody storesLow serum ferritin levelsTotal iron binding capacitySerum ferritin levelsSevere sleep onset insomniaLow body storesIron binding capacityHours of sleepSleep onset insomniaOral ironCorrectable causeExcessive daytimeSerum ferritinChronic insomniaSerum ironIron statusOnset insomniaDiagnoses Received by Narcolepsy Patients in the Year Prior to Diagnosis by a Sleep Specialist
Kryger M, Walld R, Manfreda J. Diagnoses Received by Narcolepsy Patients in the Year Prior to Diagnosis by a Sleep Specialist. Sleep 2002, 25: 36-41. PMID: 11833859, DOI: 10.1093/sleep/25.1.36.Peer-Reviewed Original ResearchConceptsOnset of symptomsSleep disorders centerCorrect diagnosisNarcolepsy patientsDisorders CenterManitoba Health databaseDiagnosis of narcolepsyNervous system disordersLonger intervalsClinical featuresExcessive daytimeNarcolepsy diagnosisNeurologic conditionsControl subjectsHypnagogic hallucinationsGeneral practitionersNeurologic disordersTeaching hospitalDoctor visitsNocturnal sleepSevere symptomatologySystem disordersGeneral populationSleep specialistsSpecialist evaluation
2000
Diagnosis and management of sleep apnea syndrome
Kryger M. Diagnosis and management of sleep apnea syndrome. Clinical Cornerstone 2000, 2: 39-44. PMID: 10875045, DOI: 10.1016/s1098-3597(00)90039-5.Peer-Reviewed Original ResearchConceptsSleep apnea syndromeApnea syndromeContinuous positive airway pressureMain presenting symptomPositive airway pressureSleep breathing disordersConstellation of signsPresenting symptomAirway pressureMost patientsExcessive daytimeSleep apneaBreathing disordersAbnormal breathingComplete resolutionSleep disruptionBusy cliniciansSymptomsSyndromeSleepDiagnosisDisordersEpisodesHypoxemiaApnea
1997
Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy
Broughton R, Fleming J, George C, Hill J, Kryger M, Moldofsky H, Montplaisir J, Morehouse R, Moscovitch A, Murphy W. Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology 1997, 49: 444-451. PMID: 9270575, DOI: 10.1212/wnl.49.2.444.Peer-Reviewed Original ResearchConceptsPlacebo-controlled crossover trialOnly significant adverse effectPlacebo-controlled trialExcessive daytime somnolenceMean sleep latencyPeriodic leg movementsEpworth Sleepiness ScaleDaytime sleep episodesInternational diagnostic criteriaSignificant adverse effectsHypertensive patientsMore nauseaBlood pressureDaily doseDaytime somnolenceExcessive daytimeSleep apneaCrossover trialSleep latencyModafinil 200Nocturnal sleepPatient's abilitySleepiness ScaleSleep initiationHeart rate
1991
Central sleep apnoea in congenital muscular dystrophy.
Kryger M, Steljes D, Yee W, Mate E, Smith S, Mahowald M. Central sleep apnoea in congenital muscular dystrophy. Journal Of Neurology Neurosurgery & Psychiatry 1991, 54: 710. PMID: 1940943, PMCID: PMC1014476, DOI: 10.1136/jnnp.54.8.710.Peer-Reviewed Original ResearchConceptsCentral sleep apnoeaSleep-disordered breathingCongenital muscular dystrophyMorning headachesSleep apnoeaNocturnal seizuresCongestive heart failureMuscular dystrophyPulmonary hypertensionClinical weaknessHeart failureExcessive daytimeNeuromuscular syndromeRespiratory dysfunctionNeuromuscular disordersApnoeaHeadacheSeizuresSymptomsBreathingDystrophyHypertensionDysfunctionSyndrome
1982
Diagnosis of sleep breathing disorders in a general hospital. Experience and recommendations.
Kryger M, Mezon B, Acres J, West P, Brownell L. Diagnosis of sleep breathing disorders in a general hospital. Experience and recommendations. JAMA Internal Medicine 1982, 142: 956-9. PMID: 7082118, DOI: 10.1001/archinte.142.5.956.Peer-Reviewed Original ResearchDiagnosis of Sleep Breathing Disorders in a General Hospital: Experience and Recommendations
Kryger M, Mezon B, Acres J, West P, Brownell L. Diagnosis of Sleep Breathing Disorders in a General Hospital: Experience and Recommendations. JAMA Internal Medicine 1982, 142: 956-958. DOI: 10.1001/archinte.1982.00340180114021.Peer-Reviewed Original Research