2008
Assessment and Management of Patients with Obesity Hypoventilation Syndrome
Mokhlesi B, Kryger MH, Grunstein RR. Assessment and Management of Patients with Obesity Hypoventilation Syndrome. Annals Of The American Thoracic Society 2008, 5: 218-225. PMID: 18250215, PMCID: PMC2645254, DOI: 10.1513/pats.200708-122mg.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObesity hypoventilation syndromeSleep-disordered breathingHypoventilation syndromeManagement of patientsAvailable treatment modalitiesRelated health care expendituresSerious cardiovascular diseaseHealth care expensesHealth care expendituresDaytime hypercapniaEucapnic patientsSignificant lungClinical characteristicsObese patientsSignificant morbidityEarly mortalityTreatment modalitiesEarly recognitionExtreme obesityCardiovascular diseaseHigh burdenEffective treatmentHigh riskHigh indexClinical practice
2006
Adaptive servo-ventilation in patients with idiopathic Cheyne-Stokes breathing.
Banno K, Okamura K, Kryger MH. Adaptive servo-ventilation in patients with idiopathic Cheyne-Stokes breathing. Journal Of Clinical Sleep Medicine 2006, 2: 181-6. PMID: 17557493, DOI: 10.5664/jcsm.26514.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureCheyne-Stokes breathingHours of sleepHeart failureBreathing patternCentral sleep apneaPositive airway pressurePeriodic breathing patternAbnormal breathing patternsSerious medical problemSubjective daytime alertnessAbnormal breathing eventsAirway pressureRenal failureMedical illnessSleep apneaStokes breathingDaytime alertnessEffective treatmentPatientsSleep respirationBreathing eventsMedical problemsDaytime performanceBreathing
1996
L-DOPA/Carbidopa for Nocturnal Movement Disorders in Uremia
Walker S, Fine A, Kryger M. L-DOPA/Carbidopa for Nocturnal Movement Disorders in Uremia. Sleep 1996, 19: 214-218. PMID: 8723378, DOI: 10.1093/sleep/19.3.214.Peer-Reviewed Original ResearchConceptsL-dopa/carbidopaRestless legs syndromeSlow-wave sleepLeg movementsSleep timeTreatment of RLSMovement arousal indexNocturnal movement disordersSingle bedtime doseChronic hemodialysis patientsPeriodic limb movementsHours of sleepBedtime doseActive medicationHemodialysis patientsCrossover studyLegs syndromeUremic patientsArousal indexMovement disordersSleep disruptionFrequent dosingObjective improvementSleep disordersEffective treatment
1992
MANAGEMENT OF OBSTRUCTIVE SLEEP APNEA
Kryger M. MANAGEMENT OF OBSTRUCTIVE SLEEP APNEA. Clinics In Chest Medicine 1992, 13: 481-492. PMID: 1521414, DOI: 10.1016/s0272-5231(21)00875-3.Peer-Reviewed Original ResearchConceptsPositive airway pressureObstructive sleep apneaAirway pressureSleep apneaNasal continuous positive airway pressureBilevel positive airway pressureContinuous positive airway pressureGeneral therapeutic measuresUpper airway abnormalitiesMinority of patientsLong-term efficacyHours of sleepHypopnea frequencyAirway abnormalitiesObese patientsSurgical managementDrug therapyTherapeutic measuresEffective treatmentPatientsSpecific abnormalitiesApneaWeight lossTreatmentAbnormalities