2001
Sleep complaints and restless legs syndrome in adult type 2 diabetics
Skomro R, Ludwig S, Salamon E, Kryger M. Sleep complaints and restless legs syndrome in adult type 2 diabetics. Sleep Medicine 2001, 2: 417-422. PMID: 14592391, DOI: 10.1016/s1389-9457(01)00110-1.Peer-Reviewed Original ResearchRestless legs syndromeAdult type 2 diabeticsType 2 diabeticsAdult diabeticsLegs syndromeSleep complaintsPresence of RLSPrevalence of RLSConsecutive type 2 diabetic patientsType 2 Adult DiabeticsType 2 diabetic patientsEpworth Sleepiness ScoreProportion of diabeticsCauses of insomniaHigh rateSensory polyneuropathyCreatinine levelsExcessive somnolenceDaytime somnolenceDiabetes mellitusDiabetic patientsHypnotic useSensory neuropathyDiabetes controlSleep Questionnaire
1999
Clinical presentations of obstructive sleep apnea syndrome
Skomro R, Kryger M. Clinical presentations of obstructive sleep apnea syndrome. Progress In Cardiovascular Diseases 1999, 41: 331-340. PMID: 10406327, DOI: 10.1053/pcad.1999.0410331.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea syndromeQuality of lifeApnea syndromeClinical presentationTreatment of OSASClinical practiceBlood pressure controlIschemic heart diseaseHealth care professionalsMiddle-aged adultsCardiovascular morbidityPulmonary hypertensionMajor sequelaeUnderrecognized disorderCardiorespiratory failureDaytime somnolenceUpper airwayPrompt evaluationHeart diseaseRisk factorsClinical impressionNeurocognitive complaintsCare professionalsPressure control
1997
Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy
Broughton R, Fleming J, George C, Hill J, Kryger M, Moldofsky H, Montplaisir J, Morehouse R, Moscovitch A, Murphy W. Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology 1997, 49: 444-451. PMID: 9270575, DOI: 10.1212/wnl.49.2.444.Peer-Reviewed Original ResearchConceptsPlacebo-controlled crossover trialOnly significant adverse effectPlacebo-controlled trialExcessive daytime somnolenceMean sleep latencyPeriodic leg movementsEpworth Sleepiness ScaleDaytime sleep episodesInternational diagnostic criteriaSignificant adverse effectsHypertensive patientsMore nauseaBlood pressureDaily doseDaytime somnolenceExcessive daytimeSleep apneaCrossover trialSleep latencyModafinil 200Nocturnal sleepPatient's abilitySleepiness ScaleSleep initiationHeart rate
1993
Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration
Biberdorf D, Steens R, Millar T, Kryger M. Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration. Sleep 1993, 16: 529-538. PMID: 8235237, DOI: 10.1093/sleep/16.6.529.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationCongestive heart failureTotal sleep timePercentage of TSTApnea/hypopnea indexOxygen saturationTotal wake timeEffects of temazepamHeart failureSleep architectureDouble-blind crossover trialSevere congestive heart failureOvernight oxygen saturationStage 1 sleepHours of sleepSleep stage proportionsCHF patientsHypopnea indexMale patientsDaytime somnolenceCrossover trialSignificant changesFrequent arousalsDaytime alertnessSleep time
1982
Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial
Brownell L, West P, Sweatman P, Acres J, Kryger M. Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial. New England Journal Of Medicine 1982, 307: 1037-1042. PMID: 6750396, DOI: 10.1056/nejm198210213071701.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTotal sleep timeApnea timeApnea durationBody weightSleep timeDouble-blind crossover studyDouble-blind trialMonths of treatmentWeeks of treatmentNocturnal oxygenationREM reductionDaytime somnolenceCrossover studyTricyclic antidepressantsApneaArousal frequencySimilar decreaseProtriptylineSimilar improvementsTreatmentOxygenationDurationSomnolence