2007
Cytokines and pathological sleep
Kapsimalis F, Basta M, Varouchakis G, Gourgoulianis K, Vgontzas A, Kryger M. Cytokines and pathological sleep. Sleep Medicine 2007, 9: 603-614. PMID: 18024171, DOI: 10.1016/j.sleep.2007.08.019.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMultiple biologic actionsObstructive sleep apneaExcessive daytime sleepinessNew biologic treatmentsChronic inflammatory diseaseHormonal regulatory mechanismsCardiovascular consequencesSleep apneaBiologic treatmentExcessive sleepinessSleep disturbancesDaytime sleepinessInflammatory diseasesSleep disordersCytokinesImmune systemBiologic actionsIntercellular mediatorsPathological sleepTarget tissuesSleepinessSleep lossImportant roleDisordersApnea
2005
Cytokines and normal sleep
Kapsimalis F, Richardson G, Opp MR, Kryger M. Cytokines and normal sleep. Current Opinion In Pulmonary Medicine 2005, 11: 481-484. PMID: 16217172, DOI: 10.1097/01.mcp.0000183062.98665.6b.Peer-Reviewed Original ResearchConceptsNon-rapid eye movement sleepEye movement sleepNeurohormonal systemsMovement sleepSpontaneous non-rapid eye movement sleepMultiple biologic actionsHypothalamic preoptic areaReceptor-mediated effectsTumor necrosis factorNitric oxide synthesisEffects of cytokinesDirect receptor-mediated effectsImmune system responseMechanism of actionSleep-wake regulationSite of actionAdrenal axisBasal forebrainPreoptic areaNecrosis factorInterleukin-1Adrenal axesNormal sleepCytokinesOxide synthesis