2002
What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis?
Smith R, Ronald J, Delaive K, Walld R, Manfreda J, Kryger MH. What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis? CHEST Journal 2002, 121: 164-172. PMID: 11796446, DOI: 10.1378/chest.121.1.164.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeBody mass indexChronic obstructive airways diseaseObstructive airways diseaseHealth care utilizationSleep apnea patientsControl subjectsApnea patientsAirway diseaseOSAS patientsCardiovascular diseaseObstructive sleep apnea patientsHealth care utilization measuresApnea-hypopnea indexCongestive heart failureEffect of obesityIschemic heart diseaseSleep apnea syndromeDegree of hypoxemiaSignificant independent predictorsLogistic regression analysisCertain cardiovascular disordersHealth care resourcesRegression analysisApnea syndromeDiagnoses Received by Narcolepsy Patients in the Year Prior to Diagnosis by a Sleep Specialist
Kryger M, Walld R, Manfreda J. Diagnoses Received by Narcolepsy Patients in the Year Prior to Diagnosis by a Sleep Specialist. Sleep 2002, 25: 36-41. PMID: 11833859, DOI: 10.1093/sleep/25.1.36.Peer-Reviewed Original ResearchConceptsOnset of symptomsSleep disorders centerCorrect diagnosisNarcolepsy patientsDisorders CenterManitoba Health databaseDiagnosis of narcolepsyNervous system disordersLonger intervalsClinical featuresExcessive daytimeNarcolepsy diagnosisNeurologic conditionsControl subjectsHypnagogic hallucinationsGeneral practitionersNeurologic disordersTeaching hospitalDoctor visitsNocturnal sleepSevere symptomatologySystem disordersGeneral populationSleep specialistsSpecialist evaluation
2001
The Use of Health-Care Resources in Obesity-Hypoventilation Syndrome
Berg G, Delaive K, Manfreda J, Walld R, Kryger M. The Use of Health-Care Resources in Obesity-Hypoventilation Syndrome. CHEST Journal 2001, 120: 377-383. PMID: 11502632, DOI: 10.1378/chest.120.2.377.Peer-Reviewed Original ResearchConceptsGeneral population control subjectsObese control subjectsObesity hypoventilation syndromeInitiation of treatmentOHS patientsControl subjectsRetrospective observational cohort studyObservational cohort studyMeasurement of BMISleep breathing disordersHealth care utilizationPopulation control subjectsSleep disorders centerHealth care resourcesCohort studyPhysician visitsBreathing disordersDisorders CenterPatientsControl groupDiagnosisPhysician feesHealth careVisitsTreatment
2000
Restless legs syndrome in 218 patients: associated disorders
Banno K, Delaive K, Walld R, Kryger M. Restless legs syndrome in 218 patients: associated disorders. Sleep Medicine 2000, 1: 221-229. PMID: 10828433, DOI: 10.1016/s1389-9457(00)00023-x.Peer-Reviewed Original ResearchRestless legs syndromeRLS patientsFemale controlsMale controlsMale patientsFemale patientsManitoba Health databasePeriodic limb movementsSleep laboratory evaluationSleep maintenance insomniaDiseases of jointsMost patientsExtrapyramidal diseasesRestless legsExtrapyramidal disordersLegs syndromePainful conditionsControl subjectsMaintenance insomniaMovement disordersGeneral populationPsychiatric disordersMusculoskeletal disordersPatientsHealth databases
1999
Health Care Utilization in Males with Obstructive Sleep Apnea Syndrome Two Years After Diagnosis and Treatment
Bahammam A, Delaive K, Ronald J, Manfreda J, Roos L, Kryger M. Health Care Utilization in Males with Obstructive Sleep Apnea Syndrome Two Years After Diagnosis and Treatment. Sleep 1999, 22: 740-747. PMID: 10505819, DOI: 10.1093/sleep/22.6.740.Peer-Reviewed Original ResearchConceptsOSA patientsGeneral populationProspective observational cohort studyObservational cohort studySubgroup of patientsSleep disorders centerTreatment of patientsTwo yearsOSAS groupCohort studyPAT groupControl subjectsDisorders CenterPhysician claimsPatientsUtilization dataOne-yearDiagnosisYears one yearTreatmentYearsCanadian provincesOSASGroupHospital
1996
Utilization of Health Care Services in Patients With Severe Obstructive Sleep Apnea
Kryger M, Roos L, Delaive K, Walld R, Horrocks J. Utilization of Health Care Services in Patients With Severe Obstructive Sleep Apnea. Sleep 1996, 19: s111-s116. PMID: 9122567, DOI: 10.1093/sleep/19.suppl_9.s111.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaHealth care servicesSleep apneaControl groupCare servicesSevere obstructive sleep apneaHealth care utilizationSleep apnea patientsObese patientsOSA patientsCare utilizationInitial diagnosisOSA groupControl subjectsApnea patientsHospital costsPhysician claimsPatientsApneaControl counterpartsHeavy consumersSpecific evaluationGroupTotal expenditureHospital
1985
Breathing during Sleep in Patients with Interstitial Lung Disease1–3
Perez-Padilla R, West P, Lertzman M, Kryger M. Breathing during Sleep in Patients with Interstitial Lung Disease1–3. American Journal Of Respiratory And Critical Care Medicine 1985, 132: 224-9. PMID: 2411177, DOI: 10.1164/arrd.1985.132.2.224.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseTi/TtotControl subjectsSleep qualityREM sleepRapid shallow breathing patternSex-matched control subjectsIncidence of snoringShallow breathing patternIncidence of apneaPoor sleep qualityAwake SaO2Lung diseaseExpiratory timeInspiratory timeLung reflexesOxygen saturationGreater abnormalitiesNREM sleepSleep structureHypopnea periodsBreathing patternPatientsVolume indexSleep
1984
Breathing Patterns in Patients with Chronic Obstructive Pulmonary Disease1,2
Loveridge B, West P, Anthonisen N, Kryger M. Breathing Patterns in Patients with Chronic Obstructive Pulmonary Disease1,2. American Journal Of Respiratory And Critical Care Medicine 1984, 130: 730-3. PMID: 6497155, DOI: 10.1164/arrd.1984.130.5.730.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCOPD groupRespiratory inductance plethysmographRib cageStable chronic obstructive pulmonary diseaseSex-matched control subjectsChronic obstructive pulmonaryObstructive pulmonary diseaseTi/TtotCOPD patientsMean PaO2Pulmonary diseaseControl subjectsMinute ventilationExpiratory timeInspiratory flowSitting positionTidal volumeNormal subjectsBreathing patternInductance plethysmographPatientsRespiratory cycleMean numberNeural control
1978
Excessive Polycythemia of High Altitude: Role of Ventilatory Drive and Lung Disease1–3
Kryger M, McCullough R, Doekel R, Collins D, Weil J, Grover R. Excessive Polycythemia of High Altitude: Role of Ventilatory Drive and Lung Disease1–3. American Journal Of Respiratory And Critical Care Medicine 1978, 118: 659-666. PMID: 707889, DOI: 10.1164/arrd.1978.118.4.659.Peer-Reviewed Original ResearchConceptsCause of hypoxemiaExcessive polycythemiaPolycythemic patientsTidal volumeNormal subjectsExcessive hypoxemiaChemical driveAbnormal breathing patternsAlveolar-arterial differenceSmall tidal volumesHigh-altitude residentsRespiratory QuestionnaireSpirometric featuresHypoxic depressionVentilatory driveLung diseaseControl subjectsVentilatory responseMinute ventilationNormal lungBreathing patternHypoxemiaPatientsPolycythemiaDead spaceImpaired Oxygenation During Sleep in Excessive Polycythemia of High Altitude: Improvement with Respiratory Stimulation
Kryger M, Glas R, Jackson D, McCullough R, Scoggin C, Grover R, Weil J. Impaired Oxygenation During Sleep in Excessive Polycythemia of High Altitude: Improvement with Respiratory Stimulation. Sleep 1978, 1: 3-17. PMID: 756057, DOI: 10.1093/sleep/1.1.3.Peer-Reviewed Original ResearchConceptsMedroxyprogesterone acetatePolycythemic patientsSevere hypoxemiaExcessive polycythemiaDouble-blind crossover trialMean lowest SaO2REM stage sleepDegree of hypoxemiaHigh-altitude residentsAwake SaO2Nocturnal SaO2Sleep hypoxemiaStage sleepImpaired oxygenationCrossover trialMean SaO2Lowest SaO2Control subjectsHypoxemiaTherapeutic effectOxygen saturationExcessive hypoxemiaSaO2Breathing patternPatients