2015
Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome
Knauert M, Naik S, Gillespie MB, Kryger M. Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome. World Journal Of Otorhinolaryngology - Head And Neck Surgery 2015, 1: 17-27. PMID: 29204536, PMCID: PMC5698527, DOI: 10.1016/j.wjorl.2015.08.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsObstructive sleep apnea syndromeSleep apnea syndromeUntreated obstructive sleep apnea syndromeApnea syndromeEffective therapyPoor patient acceptanceStart date restrictionLack of diagnosisSignificant economic burdenEnglish-language studiesExcessive daytimeSleep apneaPatient acceptanceCardiovascular diseaseClinical consequencesDate restrictionsEconomic burdenMetabolic diseasesPubMed databaseAbnormal physiologySyndromeTherapyLack of accessDiseaseTreatment
2009
Evidence‐Based Recommendations for the Assessment and Management of Sleep Disorders in Older Persons
Bloom HG, Ahmed I, Alessi CA, Ancoli‐Israel S, Buysse DJ, Kryger MH, Phillips BA, Thorpy MJ, Vitiello MV, Zee PC. Evidence‐Based Recommendations for the Assessment and Management of Sleep Disorders in Older Persons. Journal Of The American Geriatrics Society 2009, 57: 761-789. PMID: 19484833, PMCID: PMC2748127, DOI: 10.1111/j.1532-5415.2009.02220.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSpecific sleep disordersSleep disordersExpert-based recommendationsOlder personsRestless legs syndromeCircadian rhythm sleep disordersEvidence-based recommendationsSleep-related disordersPatient care practicesSerious medical problemTerm care settingsOlder adult populationMultiple medicationsPsychosocial comorbiditiesLegs syndromeSleep apneaCerebrovascular diseaseStrong bidirectional relationshipCardiovascular diseaseHigh prevalenceCare settingsSleep problemsHigh riskAmbulatory settingCare practices
2008
Assessment and Management of Patients with Obesity Hypoventilation Syndrome
Mokhlesi B, Kryger MH, Grunstein RR. Assessment and Management of Patients with Obesity Hypoventilation Syndrome. Annals Of The American Thoracic Society 2008, 5: 218-225. PMID: 18250215, PMCID: PMC2645254, DOI: 10.1513/pats.200708-122mg.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObesity hypoventilation syndromeSleep-disordered breathingHypoventilation syndromeManagement of patientsAvailable treatment modalitiesRelated health care expendituresSerious cardiovascular diseaseHealth care expensesHealth care expendituresDaytime hypercapniaEucapnic patientsSignificant lungClinical characteristicsObese patientsSignificant morbidityEarly mortalityTreatment modalitiesEarly recognitionExtreme obesityCardiovascular diseaseHigh burdenEffective treatmentHigh riskHigh indexClinical practice
2002
Cardiovascular medication use in patients with undiagnosed obstructive sleep apnoea
Otake K, Delaive K, Walld R, Manfreda J, Kryger M. Cardiovascular medication use in patients with undiagnosed obstructive sleep apnoea. Thorax 2002, 57: 417. PMID: 11978918, PMCID: PMC1746332, DOI: 10.1136/thorax.57.5.417.Peer-Reviewed Original ResearchConceptsMore daily dosesCardiovascular diseaseSystemic hypertensionMedication usePrescribed medicationsDaily dosesMore prescriptionsOdds ratioSleep apnoea/hypopnoea syndromeUndiagnosed obstructive sleep apnoeaObstructive sleep apnoeaCardiovascular medication useCongestive heart failureUse of medicationsGeneral population controlsOSAS casesMore medicationsSecondary preventionAngina pectorisHeart failureSleep apnoeaMedication costsSuch medicationsMyocardial infarctionOSAS diagnosisWhat Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis?
Smith R, Ronald J, Delaive K, Walld R, Manfreda J, Kryger MH. What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis? CHEST Journal 2002, 121: 164-172. PMID: 11796446, DOI: 10.1378/chest.121.1.164.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeBody mass indexChronic obstructive airways diseaseObstructive airways diseaseHealth care utilizationSleep apnea patientsControl subjectsApnea patientsAirway diseaseOSAS patientsCardiovascular diseaseObstructive sleep apnea patientsHealth care utilization measuresApnea-hypopnea indexCongestive heart failureEffect of obesityIschemic heart diseaseSleep apnea syndromeDegree of hypoxemiaSignificant independent predictorsLogistic regression analysisCertain cardiovascular disordersHealth care resourcesRegression analysisApnea syndrome
1998
Susceptibility of LDL to Oxidative Stress in Obstructive Sleep Apnea
Wali S, Bahammam A, Massaeli H, Pierce G, Iliskovic N, Singal P, Kryger M. Susceptibility of LDL to Oxidative Stress in Obstructive Sleep Apnea. Sleep 1998, 21: 290-296. PMID: 9595608, DOI: 10.1093/sleep/21.3.290.Peer-Reviewed Original ResearchConceptsLow-density lipoproteinObstructive sleep apneaOSA patientsNormal controlsOxidative stressSleep apneaPatient groupSevere hypoxiaSusceptibility of LDLFree radical challengeSame age groupCPAP therapySevere hypoxemiaRed blood cellsCardiovascular diseaseAntioxidant reserveGeneral populationPatientsIndividual low-density lipoproteinHours of exposureControl groupAge groupsGlutathione peroxidaseBlood cellsConjugated dienes