1997
Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy
Broughton R, Fleming J, George C, Hill J, Kryger M, Moldofsky H, Montplaisir J, Morehouse R, Moscovitch A, Murphy W. Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology 1997, 49: 444-451. PMID: 9270575, DOI: 10.1212/wnl.49.2.444.Peer-Reviewed Original ResearchConceptsPlacebo-controlled crossover trialOnly significant adverse effectPlacebo-controlled trialExcessive daytime somnolenceMean sleep latencyPeriodic leg movementsEpworth Sleepiness ScaleDaytime sleep episodesInternational diagnostic criteriaSignificant adverse effectsHypertensive patientsMore nauseaBlood pressureDaily doseDaytime somnolenceExcessive daytimeSleep apneaCrossover trialSleep latencyModafinil 200Nocturnal sleepPatient's abilitySleepiness ScaleSleep initiationHeart rate
1991
Cheyne-Stokes respiration: Stability of interacting systems in heart failure.
Kryger M, Millar T. Cheyne-Stokes respiration: Stability of interacting systems in heart failure. Chaos An Interdisciplinary Journal Of Nonlinear Science 1991, 1: 265-269. PMID: 12779924, DOI: 10.1063/1.165839.Peer-Reviewed Original Research
1985
Sleep and Control of Heart Rate
George C, Kryger M. Sleep and Control of Heart Rate. Clinics In Chest Medicine 1985, 6: 595-601. PMID: 3853478, DOI: 10.1016/s0272-5231(21)00397-x.Peer-Reviewed Original ResearchConceptsHeart rateTotal peripheral vascular resistanceSinus arrhythmiaExaggerated sinus arrhythmiaAutonomic nervous system activityPeripheral vascular resistanceTransient AV blockNormal hemoglobin concentrationAutonomic nervous activityNervous system activityHeart rate responseStages of sleepVascular resistanceBlood pressureVentricular functionCardiac outputAV blockRhythm disturbancesCarotid bodyLung inflationNervous activityREM sleepRespiratory arrhythmiaHemoglobin concentrationRespiratory rate