2007
Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea
Kryger M, Wang-Weigand S, Roth T. Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea. Sleep And Breathing 2007, 11: 159-164. PMID: 17294232, DOI: 10.1007/s11325-006-0096-4.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaNext-day residual effectsApnea-hypopnea indexSleep apneaPost-sleep questionnaireAdverse eventsSelective MT1/MT2 receptor agonistMT1/MT2 receptor agonistMT2 receptor agonistSafety of ramelteonUrinary tract infectionArterial oxygen saturationControl of breathingRespiratory inductance plethysmographyRamelteon groupPlacebo groupTract infectionsCrossover studyWashout periodDepressant effectSleep QuestionnaireHypopneic eventsRespiratory effortInsomnia treatmentOxygen saturation
1996
Treatment of Obstructive Sleep Apnea With a Self-Titrating Continuous Positive Airway Pressure (CPAP) System
Sharma S, Wali S, Pouliot Z, Peters M, Neufeld H, Kryger M. Treatment of Obstructive Sleep Apnea With a Self-Titrating Continuous Positive Airway Pressure (CPAP) System. Sleep 1996, 19: 497-501. PMID: 8865508, DOI: 10.1093/sleep/19.6.497.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureCPAP nightCPAP systemLowest arterial oxygen saturationObstructive sleep apnea syndromeContinuous positive airway pressure systemDiagnostic sleep studyNasal CPAP systemPositive airway pressureProspective clinical trialsObstructive sleep apneaSleep apnea syndromeSleep-disordered breathingArterial oxygen saturationMeasures of oxygenationTotal sleep timeLong-term useAirway pressureCPAP titrationSevere OSAAcute treatmentApnea syndromeSleep apneaArousal indexAirway stability
1993
Effects of Zolpidem and Triazolam on Sleep and Respiration in Mild to Moderate Chronic Obstructive Pulmonary Disease
Steens R, Pouliot Z, Millar T, Kryger M, George C. Effects of Zolpidem and Triazolam on Sleep and Respiration in Mild to Moderate Chronic Obstructive Pulmonary Disease. Sleep 1993, 16: 318-326. PMID: 8341892, DOI: 10.1093/sleep/16.4.318.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseModerate chronic obstructive pulmonary diseaseObstructive pulmonary diseaseEffects of zolpidemPulmonary diseaseDrug conditionsNocturnal arterial oxygen desaturationArterial oxygen desaturationApnea-hypopnea indexGroup of patientsArterial oxygen saturationNumber of awakeningsTotal sleep timeHours of sleepSignificant differencesSubjective sleep variablesNew hypnotic agentOxygen desaturationCrossover studyHypnotic agentsSleep problemsSleep qualityOxygen saturationSleep efficiencyActive drug
1991
Sleep quality in children with asthma treated with theophylline or cromolyn sodium
Avital A, Steljes D, Pasterkamp H, Kryger M, Sanchez I, Chernick V. Sleep quality in children with asthma treated with theophylline or cromolyn sodium. The Journal Of Pediatrics 1991, 119: 979-984. PMID: 1960623, DOI: 10.1016/s0022-3476(05)83062-8.Peer-Reviewed Original ResearchConceptsCromolyn sodiumTheophylline periodPlacebo-controlled trialArterial oxygen desaturationTheophylline blood levelsArterial oxygen saturationTotal sleep timeYears of ageOxygen desaturationPulmonary functionTheophylline treatmentBlood levelsChild's asthmaCentral originSleep latencyProtective effectSleep qualityOxygen saturationSleep efficiencySleep timeAsthmaMicrograms/SleepMovement timeTreatment
1989
Respiration and Abnormal Sleep in Patients with Congestive Heart Failure
Hanly B, Millar T, Steljes D, Boert R, Frais M, Kryger M. Respiration and Abnormal Sleep in Patients with Congestive Heart Failure. CHEST Journal 1989, 96: 480-488. PMID: 2766808, DOI: 10.1378/chest.96.3.480.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationCongestive heart failureStage 2 NREM sleepSlow-wave sleepSleep stage changesNREM sleepHyperpneic phaseHeart failureREM sleepAwake arterial oxygen saturationStable congestive heart failureSevere congestive heart failureStage 1Mean minimum SaO2Outcomes of patientsNumber of arousalsArterial oxygen saturationStage 1 sleepMinimum SaO2Severe hypoxemiaArterial oxygenationSignificant hypoxemiaClinical statusMean durationAbnormal sleepHeart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea
Hanly P, George C, Millar T, Kryger M. Heart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea. CHEST Journal 1989, 95: 735-739. PMID: 2924602, DOI: 10.1378/chest.95.4.735.Peer-Reviewed Original ResearchConceptsVoluntary respiratory maneuversObstructive sleep apneaHR responseSleep apneaRespiratory maneuversMueller maneuverOxygen saturationVagal toneAbsence of hypoxemiaArterial oxygen saturationHeart rate responseObstructive apneaMouth pressureApneaHR changesMale subjectsRate responseBreath holdSimilar durationValsalvaSignificant differencesSignificant correlationOSASMajor determinantWakefulness
1987
The Effect of Excessive Ethanol Ingestion on Sleep in Severe Chronic Obstructive Pulmonary Disease
Easton P, West P, Meatherall R, Brewster J, Lertzman M, Kryger M. The Effect of Excessive Ethanol Ingestion on Sleep in Severe Chronic Obstructive Pulmonary Disease. Sleep 1987, 10: 224-233. PMID: 3629084, DOI: 10.1093/sleep/10.3.224.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseSevere chronic obstructive pulmonary diseaseObstructive pulmonary diseaseSleep timePulmonary diseaseHeart rateEmphysematous chronic obstructive pulmonary diseaseExcessive ethanol ingestionSignificant O2 desaturationArterial oxygen saturationIngestion of alcoholDose of ethanolSleep stagesExcessive alcohol ingestionTotal sleep timeMean heart ratePremature ventricular contractionsCOPD altersAlcohol ingestionO2 desaturationEthanol ingestionOxygen saturationVentricular contractionsREM timeSerum ethanolDynamic in Vivo Response Characteristics of Three Oximeters: Hewlett-Packard 47201A, Biox III, and Nellcor N-100
West P, George C, Kryger M. Dynamic in Vivo Response Characteristics of Three Oximeters: Hewlett-Packard 47201A, Biox III, and Nellcor N-100. Sleep 1987, 10: 263-271. PMID: 3629089, DOI: 10.1093/sleep/10.3.263.Peer-Reviewed Original ResearchConceptsOxygen saturation measurementsHeart rateSaO2 measurementsOxygen saturationSleep apnea syndrome patientsArterial oxygen saturationPulse oximeterHewlett-Packard 47201ASyndrome patientsLinear regression analysisSaturation measurementsNellcor NOximeter sensorBiox IIIOximeterPatientsRegression analysisResponse relationshipSleepPulse oximeter sensorSaO2
1986
Breathing during Sleep in Normal Pregnant Women1–3
Brownell L, West P, Kryger M. Breathing during Sleep in Normal Pregnant Women1–3. American Journal Of Respiratory And Critical Care Medicine 1986, 133: 38-41. PMID: 3942378, DOI: 10.1164/arrd.1986.133.1.38.Peer-Reviewed Original ResearchConceptsLate pregnancyMinimal arterial oxygen saturationMaternal oxygen desaturationFrequency of apneaRespiratory sleep studiesAlveolar-arterial differenceArterial oxygen saturationFunctional residual capacityLevels of progesteroneSleep-related apneaTotal apneaOxygen desaturationMaternal oxygenationComplete polysomnographyWk gestationPregnant womenCardiac outputLast trimesterPhysiologic changesResidual volumeSupine positionSleep studiesOxygen saturationPregnancyApnea
1980
Sleep Breathing Abnormalities in Kyphoscoliosis1–3
Mezon B, West P, Israels J, Kryger M. Sleep Breathing Abnormalities in Kyphoscoliosis1–3. American Journal Of Respiratory And Critical Care Medicine 1980, 122: 617-21. PMID: 7436128, DOI: 10.1164/arrd.1980.122.4.617.Peer-Reviewed Original ResearchConceptsBreathing abnormalitiesGreater oxygen desaturationPulmonary function testsArterial oxygen saturationCor pulmonaleChronic hypoxemiaOxygen desaturationCentral apneaFunction testsClinical evidencePhysiologic disturbancesSevere kyphoscoliosisMovement sleepSevere derangementThoracic deformityArterial PCO2Oxygen saturationSevere episodesChemical driveAbnormalitiesSleepPatientsDerangementPulmonaleHypoxemia