2021
Can the complete blood count be used as a reliable screening tool for obstructive sleep apnea?
Cummins E, Waseem R, Piyasena D, Wang CY, Suen C, Ryan C, Wong J, Kryger M, Chung F. Can the complete blood count be used as a reliable screening tool for obstructive sleep apnea? Sleep And Breathing 2021, 26: 613-620. PMID: 34185230, DOI: 10.1007/s11325-021-02383-3.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexComplete blood countMean SpO2Intermittent hypoxiaBlood countScreening toolObstructive sleep apneaMean oxygen saturationBody mass indexMethodsThis retrospective studyNormal clinical rangeObstructive sleep apnea screeningHome sleep studiesReliable screening toolSleep apnea screeningSevere OSAOSA severityRed blood cellsSurgical patientsIndependent predictorsMass indexSleep apneaAHI scoreRetrospective studySleep studies
2019
Centers for Medicare and Medicaid Services Positive Airway Pressure Adherence Criteria May Limit Treatment to Many Medicare Beneficiaries.
Naik S, Al-Halawani M, Kreinin I, Kryger M. Centers for Medicare and Medicaid Services Positive Airway Pressure Adherence Criteria May Limit Treatment to Many Medicare Beneficiaries. Journal Of Clinical Sleep Medicine 2019, 15: 245-251. PMID: 30736874, PMCID: PMC6374085, DOI: 10.5664/jcsm.7626.Peer-Reviewed Original ResearchConceptsEvents/hAdherence criteriaPAP treatmentObstructive sleep apnea treatmentPositive airway pressure devicesWithholding of therapyApnea-hypopnea indexObstructive sleep apneaSleep apnea treatmentMedicaid Services reimbursementAdherence reportsBaseline characteristicsPAP devicesPAP adherenceAdherent participantsApnea treatmentSleep apneaNonadherent participantsAdherence dataMedicare beneficiariesAdherence patternsCMS criteriaAdherence expectationsPatientsMonths
2018
0479 Novel Flow Limitation/Obstruction With Recovery Breath (FLOW) Event Identifies Obstructive Burden In Mild Obstructive Sleep Apnea
Johnson K, Johnson D, Visintainer P, Kryger M, Thomas R, Linderauer P, Feldmann E. 0479 Novel Flow Limitation/Obstruction With Recovery Breath (FLOW) Event Identifies Obstructive Burden In Mild Obstructive Sleep Apnea. Sleep 2018, 41: a181-a181. DOI: 10.1093/sleep/zsy061.478.Peer-Reviewed Original ResearchMild obstructive sleep apneaObstructive sleep apneaHome sleep apnea testingRespiratory-related arousalsObstructive eventsSleep apneaMild OSA patientsApnea-hypopnea indexIdentification of patientsSleep apnea testingSeverity of diseaseFlow scoreOSA patientsApnea testingAdverse outcomesMild patientsPolysomnography studiesClinical significancePatientsSignificant gender differencesApneaDesaturationAirflow disruptionObstructionArousal data1134 A morbidly obese type I diabetic teenager with sleep apnea, nocturnal eating, and Cushingoid features. Where to start?
Hawkins M, Williams C, Kryger M. 1134 A morbidly obese type I diabetic teenager with sleep apnea, nocturnal eating, and Cushingoid features. Where to start? Sleep 2018, 41: a419-a420. DOI: 10.1093/sleep/zsy063.1133.Peer-Reviewed Original ResearchObstructive sleep apneaMorning glucose levelsNocturnal eatingSleep apneaGlucose levelsDocumentation of hypoglycemiaInsulin resistance riskApnea-hypopnea indexSetting of diabetesBody mass indexDoses of insulinDiagnosis of diabetesAge 5 yearsAdverse health conditionsSalivary cortisol levelsType ICushingoid featuresPAP therapyCushingoid appearanceNight sweatsHypopnea indexHypothalamic dysfunctionPrompt treatmentCushing's diseaseNight-time behavior
2015
The Use of a Fully Automated Automatic Adaptive Servoventilation Algorithm in the Acute and Long-term Treatment of Central Sleep Apnea
Javaheri S, Winslow D, McCullough P, Wylie P, Kryger MH. The Use of a Fully Automated Automatic Adaptive Servoventilation Algorithm in the Acute and Long-term Treatment of Central Sleep Apnea. CHEST Journal 2015, 148: 1454-1461. PMID: 25950507, DOI: 10.1378/chest.14-2966.Peer-Reviewed Original ResearchConceptsCentral apnea indexApnea-hypopnea indexCentral sleep apneaSleep apneaSleep qualityComplex sleep-disordered breathingASV deviceASV titrationAdaptive servoventilation devicesCongestive heart failureMonths of treatmentSleep-disordered breathingEpworth Sleepiness ScaleLong-term treatmentImproved sleep qualityMixed sleep apneaBetter sleep qualityApnea indexHeart failureObservational trialObstructive apneaBreathing disordersInspiratory pressureArousal indexDaytime sleepinessEffects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease
Sun H, Palcza J, Rosenberg R, Kryger M, Siringhaus T, Rowe J, Lines C, Wagner JA, Troyer MD. Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease. Respiratory Medicine 2015, 109: 416-426. PMID: 25661282, DOI: 10.1016/j.rmed.2014.12.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAzepinesCross-Over StudiesDouble-Blind MethodFemaleHumansMaleMiddle AgedOrexin Receptor AntagonistsPulmonary Disease, Chronic ObstructiveRespirationSeverity of Illness IndexSleepSleep Aids, PharmaceuticalSpirometryTreatment OutcomeTriazolesUnited StatesConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseSleep breathing disordersOrexin receptor antagonistPulmonary diseaseBreathing disordersReceptor antagonistModerate chronic obstructive pulmonary diseaseDay 4Effects of suvorexantModerate airflow limitationRespiratory depressant effectsApnea-hypopnea indexMaximum daily doseClinical research unitTotal sleep timeTreatment of insomniaMean AHICOPD patientsAirflow limitationHypopnea indexDaily doseMean SpO2Spirometry criteriaHypnotic medications
2011
Positive Airway Pressure Initiation: A Randomized Controlled Trial to Assess the Impact of Therapy Mode and Titration Process on Efficacy, Adherence, and Outcomes
Kushida CA, Berry RB, Blau A, Crabtree T, Fietze I, Kryger MH, Kuna ST, Pegram GV, Penzel T. Positive Airway Pressure Initiation: A Randomized Controlled Trial to Assess the Impact of Therapy Mode and Titration Process on Efficacy, Adherence, and Outcomes. Sleep 2011, 34: 1083-1092. PMID: 21804670, PMCID: PMC3138163, DOI: 10.5665/sleep.1166.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureMinimum oxygen saturationAirway pressureFunctional outcomeOxygen saturationVeterans Affairs Medical CenterPositive pressure treatmentApnea-hypopnea indexObstructive sleep apneaSevere OSAMulticenter trialTreatment satisfactionControlled TrialsSleep apneaMajor efficacyStudy treatmentOutcome measuresMedical CenterSleep qualityTherapy modesMask comfortAdherenceEfficacyMonths
2010
Prediction of obstructive sleep apnea syndrome in a large Greek population
Bouloukaki I, Kapsimalis F, Mermigkis C, Kryger M, Tzanakis N, Panagou P, Moniaki V, Vlachaki EM, Varouchakis G, Siafakas NM, Schiza SE. Prediction of obstructive sleep apnea syndrome in a large Greek population. Sleep And Breathing 2010, 15: 657-664. PMID: 20872180, DOI: 10.1007/s11325-010-0416-6.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeApnea-hypopnea indexBody mass indexSleep apnea syndromeApnea syndromeSignificant clinical predictorsInitiation of treatmentLogistic regression analysisSelf-reported symptomsEDS severityNinety patientsSleepiness severityClinical predictorsIndependent predictorsPSG evaluationMass indexDiagnostic polysomnographyHip circumferenceClinical indicesScore 10High riskAnthropometric measurementsScore 4Predictive valuePatients
2008
The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease
Kryger M, Roth T, Wang-Weigand S, Zhang J. The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease. Sleep And Breathing 2008, 13: 79-84. PMID: 18584227, DOI: 10.1007/s11325-008-0196-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultComorbidityCross-Over StudiesDouble-Blind MethodFemaleHumansIndenesMaleOximetryPolysomnographyPulmonary Disease, Chronic ObstructiveReceptors, MelatoninSeverity of Illness IndexSleep Apnea SyndromesSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersSleep StagesYoung AdultConceptsSevere chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseEffects of ramelteonObstructive pulmonary diseasePulmonary diseaseMean SaO2Respiratory depressant effectsApnea-hypopnea indexPoor sleep qualityTotal sleep timeMelatonin receptor agonistResultsNo significant differencesSignificant differencesAbnormal breathing eventsRamelteon 8Primary endpointAdverse eventsPersistent sleepCrossover studyDepressant effectPolysomnographic monitoringReceptor agonistRespiratory effortInsomnia treatmentSleep quality
2007
Effect of Ramelteon, a selective MT1/MT2-receptor agonist, on respiration during sleep in mild to moderate COPD
Kryger M, Wang-Weigand S, Zhang J, Roth T. Effect of Ramelteon, a selective MT1/MT2-receptor agonist, on respiration during sleep in mild to moderate COPD. Sleep And Breathing 2007, 12: 243-250. PMID: 18060441, DOI: 10.1007/s11325-007-0156-4.Peer-Reviewed Original ResearchConceptsModerate chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseAbnormal breathing eventsSelective MT1/MT2 receptor agonistMT1/MT2 receptor agonistMean apnea-hypopnea indexBreathing eventsEffects of ramelteonMT2 receptor agonistSingle bedtime doseApnea-hypopnea indexObstructive pulmonary diseaseNumber of awakeningsTotal sleep timeMelatonin receptor agonistBedtime dosePlacebo groupAdverse eventsPulmonary diseaseCrossover studyPhysical examinationReceptor agonistSleep efficiencySleep durationSleep timeSafety of ramelteon in individuals with mild to moderate obstructive sleep apnea
Kryger M, Wang-Weigand S, Roth T. Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea. Sleep And Breathing 2007, 11: 159-164. PMID: 17294232, DOI: 10.1007/s11325-006-0096-4.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaNext-day residual effectsApnea-hypopnea indexSleep apneaPost-sleep questionnaireAdverse eventsSelective MT1/MT2 receptor agonistMT1/MT2 receptor agonistMT2 receptor agonistSafety of ramelteonUrinary tract infectionArterial oxygen saturationControl of breathingRespiratory inductance plethysmographyRamelteon groupPlacebo groupTract infectionsCrossover studyWashout periodDepressant effectSleep QuestionnaireHypopneic eventsRespiratory effortInsomnia treatmentOxygen saturation
2006
Gender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome
Vagiakis E, Kapsimalis F, Lagogianni I, Perraki H, Minaritzoglou A, Alexandropoulou K, Roussos C, Kryger M. Gender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome. Sleep Medicine 2006, 7: 424-430. PMID: 16740405, DOI: 10.1016/j.sleep.2005.12.014.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeApnea-hypopnea indexBody mass indexSleep apnea syndromeMale patientsApnea syndromeFemale patientsOnset latencyMean apnea-hypopnea indexSleep apnea hypopnea indexHigher apnea-hypopnea indexNon-rapid eye movement sleepSleep disorders centerREM onset latencyEye movement sleepAthens Medical SchoolPercent of menSleep efficiency indexTotal sleep timeGreek subjectsAspects of sleepSleep onset latencyNorth American clinicsEvangelismos HospitalNREM-AHI
2005
Utilization of Healthcare Resources in Obstructive Sleep Apnea Syndrome: a 5Year Follow-Up Study in Men Using CPAP
Albarrak M, Banno K, Sabbagh AA, Delaive K, Walld R, Manfreda J, Kryger MH. Utilization of Healthcare Resources in Obstructive Sleep Apnea Syndrome: a 5Year Follow-Up Study in Men Using CPAP. Sleep 2005, 28: 1306-1311. PMID: 16295216, DOI: 10.1093/sleep/28.10.1306.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea syndromeIschemic heart diseaseHealthcare utilizationApnea syndromeHeart diseaseTreatment of OSASContinuous positive airway pressure useUntreated obstructive sleep apnea syndromeRetrospective observational cohort studyPositive airway pressure useEpworth Sleepiness Scale scoreLong-term health benefitsHigher healthcare utilizationObservational cohort studyApnea-hypopnea indexBody mass indexCPAP treatmentCohort studyPhysician visitsMass indexEligible menOSAS diagnosisFifth yearOSA diagnosisLong-term treatment of sleep breathing disorder in a patient with Huntington's disease
Banno K, Hobson DE, Kryger MH. Long-term treatment of sleep breathing disorder in a patient with Huntington's disease. Parkinsonism & Related Disorders 2005, 11: 261-264. PMID: 15878590, DOI: 10.1016/j.parkreldis.2005.01.005.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep breathing disordersApnea-hypopnea indexBreathing disordersHuntington's diseaseRapid eye movement (REM) sleepPositive airway pressureObstructive sleep apneaLong-term treatmentEye movement sleepQuality of lifeAutosomal dominant neurodegenerative disorderAirway pressureHD patientsSleep apneaRespiratory arousalsMovement sleepDominant neurodegenerative disorderDaytime alertnessSleep structureNeurodegenerative disordersDiseaseDisordersApneaPatientsDifferences between Men and Women in the Clinical Presentation of Patients Diagnosed with Obstructive Sleep Apnea Syndrome
Shepertycky M, Banno K, Kryger MH. Differences between Men and Women in the Clinical Presentation of Patients Diagnosed with Obstructive Sleep Apnea Syndrome. Sleep 2005, 28: 309-314. PMID: 16173651, DOI: 10.1093/sleep/28.3.309.Peer-Reviewed Original ResearchConceptsEpworth Sleepiness Scale scoreApnea-hypopnea indexBody mass indexClinical presentationMass indexObstructive sleep apnea syndrome (OSA) resultsTertiary university-based medical centerScale scoreRetrospective chart review analysisObstructive sleep apnea syndromeUniversity-based medical centerLaboratory polysomnographic studiesMain presenting symptomChart review analysisUpper airway anatomySleep apnea syndromeHistory of depressionGender-related differencesLess alcohol consumptionPolysomnographic findingsPresenting symptomApnea syndromeHypothyroid diseasePolysomnographic studyPrimary complaint
2002
What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis?
Smith R, Ronald J, Delaive K, Walld R, Manfreda J, Kryger MH. What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis? CHEST Journal 2002, 121: 164-172. PMID: 11796446, DOI: 10.1378/chest.121.1.164.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeBody mass indexChronic obstructive airways diseaseObstructive airways diseaseHealth care utilizationSleep apnea patientsControl subjectsApnea patientsAirway diseaseOSAS patientsCardiovascular diseaseObstructive sleep apnea patientsHealth care utilization measuresApnea-hypopnea indexCongestive heart failureEffect of obesityIschemic heart diseaseSleep apnea syndromeDegree of hypoxemiaSignificant independent predictorsLogistic regression analysisCertain cardiovascular disordersHealth care resourcesRegression analysisApnea syndrome
2001
Radiofrequency tissue reduction of the palate in patients with moderate sleep-disordered breathing.
Brown D, Kerr P, Kryger M. Radiofrequency tissue reduction of the palate in patients with moderate sleep-disordered breathing. Journal Of Otolaryngology 2001, 30: 193-8. PMID: 11771028, DOI: 10.2310/7070.2001.19696.Peer-Reviewed Original ResearchConceptsModerate sleep-disordered breathingSleep-disordered breathingApnea-hypopnea indexMild sleep-disordered breathingRadiofrequency tissue ablationRadiofrequency tissue reductionSt. Boniface HospitalClinically significant differencesResponse to treatmentEpworth Sleepiness ScalePost-treatment groupSoft palate tissueApnea-HypopneaArousal indexClinical efficacyEffects of treatmentPalatal tissueSoft palateFollow-upTissue reductionDaytime sleepinessRadiofrequency energySleepiness ScalePatientsSleep parameters
1993
Effects of Zolpidem and Triazolam on Sleep and Respiration in Mild to Moderate Chronic Obstructive Pulmonary Disease
Steens R, Pouliot Z, Millar T, Kryger M, George C. Effects of Zolpidem and Triazolam on Sleep and Respiration in Mild to Moderate Chronic Obstructive Pulmonary Disease. Sleep 1993, 16: 318-326. PMID: 8341892, DOI: 10.1093/sleep/16.4.318.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseModerate chronic obstructive pulmonary diseaseObstructive pulmonary diseaseEffects of zolpidemPulmonary diseaseDrug conditionsNocturnal arterial oxygen desaturationArterial oxygen desaturationApnea-hypopnea indexGroup of patientsArterial oxygen saturationNumber of awakeningsTotal sleep timeHours of sleepSignificant differencesSubjective sleep variablesNew hypnotic agentOxygen desaturationCrossover studyHypnotic agentsSleep problemsSleep qualityOxygen saturationSleep efficiencyActive drug
1989
The effect of oxygen on respiration and sleep in patients with congestive heart failure.
Hanly P, Millar T, Steljes D, Baert R, Frais M, Kryger M. The effect of oxygen on respiration and sleep in patients with congestive heart failure. Annals Of Internal Medicine 1989, 111: 777-82. PMID: 2817624, DOI: 10.7326/0003-4819-111-10-777.Peer-Reviewed Original ResearchConceptsStable congestive heart failureCheyne-Stokes respirationCongestive heart failureHeart failureTotal sleep timeOxygen therapySleep timeStage 1 NREM sleepPlacebo-controlled crossover studyLow-flow oxygenNocturnal oxygen saturationNocturnal oxygen therapyOutpatient cardiology clinicApnea-hypopnea indexNumber of arousalsStage 1 sleepStage 2 sleepSlow-wave sleepHyperpneic phaseNocturnal hypoxemiaSleep hypoxemiaMale patientsNasal cannulaeCardiology clinicCrossover study
1988
Identification and Quantification of Apneas by Computer-based Analysis of Oxygen Saturation
George C, Millar T, Kryger M. Identification and Quantification of Apneas by Computer-based Analysis of Oxygen Saturation. American Journal Of Respiratory And Critical Care Medicine 1988, 137: 1238-1240. PMID: 3195821, DOI: 10.1164/ajrccm/137.5.1238.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexApnea-hypopnea eventsNight polysomnogramsObstructive sleep apneaSleep apneaOvernight studyOxygen saturationSaO2 changesPredictive valueFalse negative rateApneaApnea eventsPolysomnogramSaO2 dataMethod of detectionOverall numberDurationNegative rateTotal numberManual scoringSaO2Patients