2021
Comorbid Insomnia and Sleep Apnea: mechanisms and implications of an underrecognized and misinterpreted sleep disorder
Meira E Cruz M, Kryger MH, Morin CM, Palombini L, Salles C, Gozal D. Comorbid Insomnia and Sleep Apnea: mechanisms and implications of an underrecognized and misinterpreted sleep disorder. Sleep Medicine 2021, 84: 283-288. PMID: 34214960, DOI: 10.1016/j.sleep.2021.05.043.Peer-Reviewed Original Research
2018
Flow limitation/obstruction with recovery breath (FLOW) event for improved scoring of mild obstructive sleep apnea without electroencephalography
Johnson KG, Johnson DC, Thomas RJ, Feldmann E, Lindenauer PK, Visintainer P, Kryger MH. Flow limitation/obstruction with recovery breath (FLOW) event for improved scoring of mild obstructive sleep apnea without electroencephalography. Sleep Medicine 2018, 67: 249-255. PMID: 30583916, PMCID: PMC6548700, DOI: 10.1016/j.sleep.2018.11.014.Peer-Reviewed Original ResearchConceptsApnea/hypopnea indexObstructive sleep apneaMild obstructive sleep apneaSleep apneaAirflow disruptionIntraclass correlationAHI categoriesBaseline PSGHypopnea indexOSA patientsHighest tertileOSA categoriesArousal criteriaPatientsFlow limitationApneaDesaturationFlow scoreArousal eventsOverall kappaObstructionTraining periodHigher proportionElectroencephalographyScoring0479 Novel Flow Limitation/Obstruction With Recovery Breath (FLOW) Event Identifies Obstructive Burden In Mild Obstructive Sleep Apnea
Johnson K, Johnson D, Visintainer P, Kryger M, Thomas R, Linderauer P, Feldmann E. 0479 Novel Flow Limitation/Obstruction With Recovery Breath (FLOW) Event Identifies Obstructive Burden In Mild Obstructive Sleep Apnea. Sleep 2018, 41: a181-a181. DOI: 10.1093/sleep/zsy061.478.Peer-Reviewed Original ResearchMild obstructive sleep apneaObstructive sleep apneaHome sleep apnea testingRespiratory-related arousalsObstructive eventsSleep apneaMild OSA patientsApnea-hypopnea indexIdentification of patientsSleep apnea testingSeverity of diseaseFlow scoreOSA patientsApnea testingAdverse outcomesMild patientsPolysomnography studiesClinical significancePatientsSignificant gender differencesApneaDesaturationAirflow disruptionObstructionArousal data
2016
Positive Airway Pressure Therapy for Obstructive Sleep Apnea
Weiss P, Kryger M. Positive Airway Pressure Therapy for Obstructive Sleep Apnea. Otolaryngologic Clinics Of North America 2016, 49: 1331-1341. PMID: 27720457, DOI: 10.1016/j.otc.2016.07.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPositive airway pressureObstructive sleep apneaAirway pressureSleep apneaMild obstructive sleep apneaPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaObstructive sleep apnea syndromeSleep-related breathing disordersConcomitant cardiovascular disordersAirway pressure therapyFirst-line therapySleep apnea syndromeAdaptive support ventilationEvaluation of adherenceEffectiveness of treatmentApnea syndromeSupport ventilationBreathing disordersPressure therapyCardiovascular disordersApneaTherapyPressure support
2011
Is Laryngeal Descent Associated With Increased Risk for Obstructive Sleep Apnea?
Yamashiro Y, Kryger M. Is Laryngeal Descent Associated With Increased Risk for Obstructive Sleep Apnea? CHEST Journal 2011, 141: 1407-1413. PMID: 22016482, DOI: 10.1378/chest.10-3238.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaAirway lengthSleep apneaJapanese patientsVocal cordsUpper airway lengthLogistic regression analysisMultislice CT scanOSA severityConsecutive patientsUpper airwayRisk factorsCT scanBMIPatientsALVCAHILow laryngeal positionLaryngeal positionCollapsible segmentApneaRegression analysisCordLarynxWomenA Novel Nasal Expiratory Positive Airway Pressure (EPAP) Device for the Treatment of Obstructive Sleep Apnea: A Randomized Controlled Trial
Berry RB, Kryger MH, Massie CA. A Novel Nasal Expiratory Positive Airway Pressure (EPAP) Device for the Treatment of Obstructive Sleep Apnea: A Randomized Controlled Trial. Sleep 2011, 34: 479-485. PMID: 21461326, PMCID: PMC3065258, DOI: 10.1093/sleep/34.4.479.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaPositive airway pressure devicesSleep apneaSham deviceWeek 1Double-blind clinical trialSevere obstructive sleep apneaMonths of treatmentSleep disorders centerEpworth Sleepiness ScalePressure deviceSubjective daytime sleepinessNon-consecutive nightsControlled TrialsMonth 3Sham treatmentClinical trialsDaytime sleepinessITT groupDisorders CenterSleepiness ScaleAHI valuesApneaMedian percentageAHI
2007
Obstructive Sleep Apnea in Pregnancy
Kapsimalis F, Kryger M. Obstructive Sleep Apnea in Pregnancy. Sleep Medicine Clinics 2007, 2: 603-613. DOI: 10.1016/j.jsmc.2007.07.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsObstructive sleep apnea syndromeSleep-disordered breathingPregnant womenTreatment of OSASDiagnosis of OSASTreatment of SDBObese pregnant womenComplications of pregnancyOutcome of pregnancyObstructive sleep apneaSleep apnea syndromeManagement of pregnancyApnea syndromeSleep apneaHormonal alterationsFetal healthEarly recognitionHigh indexPregnancyNormal sleepRespiratory systemWomenTreatmentHypertensionApneaCytokines and pathological sleep
Kapsimalis F, Basta M, Varouchakis G, Gourgoulianis K, Vgontzas A, Kryger M. Cytokines and pathological sleep. Sleep Medicine 2007, 9: 603-614. PMID: 18024171, DOI: 10.1016/j.sleep.2007.08.019.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMultiple biologic actionsObstructive sleep apneaExcessive daytime sleepinessNew biologic treatmentsChronic inflammatory diseaseHormonal regulatory mechanismsCardiovascular consequencesSleep apneaBiologic treatmentExcessive sleepinessSleep disturbancesDaytime sleepinessInflammatory diseasesSleep disordersCytokinesImmune systemBiologic actionsIntercellular mediatorsPathological sleepTarget tissuesSleepinessSleep lossImportant roleDisordersApnea
2005
Long-term treatment of sleep breathing disorder in a patient with Huntington's disease
Banno K, Hobson DE, Kryger MH. Long-term treatment of sleep breathing disorder in a patient with Huntington's disease. Parkinsonism & Related Disorders 2005, 11: 261-264. PMID: 15878590, DOI: 10.1016/j.parkreldis.2005.01.005.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep breathing disordersApnea-hypopnea indexBreathing disordersHuntington's diseaseRapid eye movement (REM) sleepPositive airway pressureObstructive sleep apneaLong-term treatmentEye movement sleepQuality of lifeAutosomal dominant neurodegenerative disorderAirway pressureHD patientsSleep apneaRespiratory arousalsMovement sleepDominant neurodegenerative disorderDaytime alertnessSleep structureNeurodegenerative disordersDiseaseDisordersApneaPatientsAuto-Titrating Continuous Positive Airway Pressure for Heart Failure Patients With Cheyne-Stokes Respiration and Central Sleep Apnea
Banno K, Okamura K, Kryger MH. Auto-Titrating Continuous Positive Airway Pressure for Heart Failure Patients With Cheyne-Stokes Respiration and Central Sleep Apnea. Circulation Journal 2005, 69: 1295. PMID: 16200689, DOI: 10.1253/circj.69.1295.Peer-Reviewed Original Research
2000
Diagnosis and management of sleep apnea syndrome
Kryger M. Diagnosis and management of sleep apnea syndrome. Clinical Cornerstone 2000, 2: 39-44. PMID: 10875045, DOI: 10.1016/s1098-3597(00)90039-5.Peer-Reviewed Original ResearchConceptsSleep apnea syndromeApnea syndromeContinuous positive airway pressureMain presenting symptomPositive airway pressureSleep breathing disordersConstellation of signsPresenting symptomAirway pressureMost patientsExcessive daytimeSleep apneaBreathing disordersAbnormal breathingComplete resolutionSleep disruptionBusy cliniciansSymptomsSyndromeSleepDiagnosisDisordersEpisodesHypoxemiaApnea
1999
DECISION MAKING IN OBSTRUCTIVE SLEEP-DISORDERED BREATHING Putting It All Together
Bahammam A, Kryger M. DECISION MAKING IN OBSTRUCTIVE SLEEP-DISORDERED BREATHING Putting It All Together. Otolaryngologic Clinics Of North America 1999, 32: 333-348. PMID: 10385540, DOI: 10.1016/s0030-6665(05)70133-x.Peer-Reviewed Original Research
1998
DECISION MAKING IN OBSTRUCTIVE SLEEP-DISORDERED BREATHING Putting it all Together
Bahammam A, Kryger M. DECISION MAKING IN OBSTRUCTIVE SLEEP-DISORDERED BREATHING Putting it all Together. Clinics In Chest Medicine 1998, 19: 87-97. PMID: 9554220, DOI: 10.1016/s0272-5231(05)70434-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1997
Using Self-Reported Questionnaire Data to Prioritize OSA Patients for Polysomnography
Pouliot Z, Peters M, Neufeld H, Kryger M. Using Self-Reported Questionnaire Data to Prioritize OSA Patients for Polysomnography. Sleep 1997, 20: 232-236. PMID: 9178919, DOI: 10.1093/sleep/20.3.232.Peer-Reviewed Original ResearchConceptsBody mass indexEpworth Sleepiness ScaleObstructive sleep apneaSimple clinical dataPercent of casesAnalysis of receiverHundreds of patientsLow AIObserved apneaApnea indexOSA patientsConsecutive patientsSleep apneaMass indexSelf-reported questionnaire dataClinical dataSleepiness ScalePatientsApneaPolysomnographyCharacteristic curveQuestionnaire dataGroupQuestionnaireSubjects
1996
Utilization of Health Care Services in Patients With Severe Obstructive Sleep Apnea
Kryger M, Roos L, Delaive K, Walld R, Horrocks J. Utilization of Health Care Services in Patients With Severe Obstructive Sleep Apnea. Sleep 1996, 19: s111-s116. PMID: 9122567, DOI: 10.1093/sleep/19.suppl_9.s111.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaHealth care servicesSleep apneaControl groupCare servicesSevere obstructive sleep apneaHealth care utilizationSleep apnea patientsObese patientsOSA patientsCare utilizationInitial diagnosisOSA groupControl subjectsApnea patientsHospital costsPhysician claimsPatientsApneaControl counterpartsHeavy consumersSpecific evaluationGroupTotal expenditureHospital
1995
Snoring and Sleep Apnea: Personal and Family Guide to Diagnosis and Treatment. Ralph A. Pascualy , Sally Warren Soest
Kryger M. Snoring and Sleep Apnea: Personal and Family Guide to Diagnosis and Treatment. Ralph A. Pascualy , Sally Warren Soest. The Quarterly Review Of Biology 1995, 70: 542-543. DOI: 10.1086/419250.Peer-Reviewed Original ResearchMedical treatment of sleep apnea
Wali S, Kryger M. Medical treatment of sleep apnea. Current Opinion In Pulmonary Medicine 1995, 1: 498-503. PMID: 9363089, DOI: 10.1097/00063198-199511000-00012.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSleep apneaContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureAirway pressure therapyPositive airway pressureObstructive sleep apneaCurrent treatment optionsTreatment of choiceAirway pressureNicotine treatmentPressure therapyTreatment optionsCommon disorderMedical treatmentDifficult patientsElectrical stimulationWeight lossDental appliancesApneaTherapyTreatmentUnwanted effectsTracheostomyPatientsSuccessful Treatment of Comorbid Panic Disorder and Sleep Apnea With Continuous Positive Airway Pressure
Enns M, Stein M, Kryger M. Successful Treatment of Comorbid Panic Disorder and Sleep Apnea With Continuous Positive Airway Pressure. Journal Of The Academy Of Consultation-Liaison Psychiatry 1995, 36: 585-586. PMID: 7501792, DOI: 10.1016/s0033-3182(95)71620-6.Peer-Reviewed Original Research
1994
Why Should Sleep Apnea Be Diagnosed and Treated?
Yamashiro Y, Kryger M. Why Should Sleep Apnea Be Diagnosed and Treated? Clinical Pulmonary Medicine 1994, 1: 250-259. DOI: 10.1097/00045413-199407000-00007.Peer-Reviewed Original ResearchNasal continuous positive airway pressureObstructive sleep apneaSevere sequelaeRepetitive upper airway obstructionsContinuous positive airway pressureUpper airway obstructionPositive airway pressureTreatment of choiceGoal of treatmentPrimary pathophysiologic eventEffect of treatmentAirway obstructionAirway pressureSevere complicationsPatients' qualitySleep apneaMultisystem dysfunctionPathophysiologic eventsCommon disorderUndiagnosed patientsSevere casesSequelaePatient's lifeApneaPatientsAcute Effect of Nasal CPAP on Periodic Limb Movements Associated with Breathing Disorders During Sleep
Yamashiro Y, Kryger M. Acute Effect of Nasal CPAP on Periodic Limb Movements Associated with Breathing Disorders During Sleep. Sleep 1994, 17: 172-175. PMID: 8036372, DOI: 10.1093/sleep/17.2.172.Peer-Reviewed Original ResearchConceptsNasal continuous positive airway pressurePeriodic limb movementsSleep-disordered breathingPLMS indexAcute effectsContinuous positive airway pressureLimb movementsSplit-night protocolPositive airway pressureNCPAP treatmentNasal CPAPAirway pressureBreathing disordersBreathingTreatmentFuture investigationsApneaCPAPPatientsSleep