2015
Periosteal PTHrP Regulates Cortical Bone Remodeling During Fracture Healing
Wang M, Nasiri AR, Broadus AE, Tommasini SM. Periosteal PTHrP Regulates Cortical Bone Remodeling During Fracture Healing. Bone 2015, 81: 104-111. PMID: 26164475, PMCID: PMC4641003, DOI: 10.1016/j.bone.2015.07.008.Peer-Reviewed Original ResearchConceptsFracture healingPTHrP expressionCKO miceCortical bone surfaceFracture repairTibial fracture surgeryRole of PTHrPHormone-related proteinTibial fracture modelCartilaginous callus formationConditional knockout miceBone surfaceCortical bone remodelingType I receptorCD1 controlsFracture surgeryCD1 miceKnockout miceInitial genetic evidencePTHrPOsteoblastic activityBone remodelingMiceBone mineralizationI receptor
2008
Regulation of embryonic endochondral ossification by Smurf2
Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN. Regulation of embryonic endochondral ossification by Smurf2. Journal Of Orthopaedic Research® 2008, 26: 704-712. PMID: 18176945, PMCID: PMC2636972, DOI: 10.1002/jor.20563.Peer-Reviewed Original ResearchConceptsOverexpression of Smurf2Embryonic endochondral ossificationChondrocyte maturationTGF-beta receptorsEndochondral ossificationTGF-beta signalingGrowth plate chondrocytesPrimary articular chondrocytesHistological analysisSmurf2 expressionChick growth plateGrowth plateHypertrophic differentiationMaturational stagesType X collagenLong bonesMRNA levelsSmurf2 levelsOssificationProliferative stageArticular chondrocytesChondrocytesSmurf2X collagenEctopic overexpression