Smad1 plays an essential role in bone development and postnatal bone formation
Wang M, Jin H, Tang D, Huang S, Zuscik MJ, Chen D. Smad1 plays an essential role in bone development and postnatal bone formation. Osteoarthritis And Cartilage 2011, 19: 751-762. PMID: 21420501, PMCID: PMC3113680, DOI: 10.1016/j.joca.2011.03.004.Peer-Reviewed Original ResearchConceptsPostnatal bone formationBone developmentCKO miceAlkaline phosphatase activityCalvarial bone developmentRole of Smad1Essential roleGene expression analysisBone formationOsteoblast-specific deletionCol2a1-Cre transgenic miceTransgenic miceBMP signalingSmad1 geneRelative gene expressionExpression analysisGene expressionConditional knockout miceOsteopenic phenotypeSmad1Formation assaysPhosphatase activityPrimary cellsOsteoblast proliferationKnockout mice