2013
Deletion of the Transforming Growth Factor β Receptor Type II Gene in Articular Chondrocytes Leads to a Progressive Osteoarthritis‐like Phenotype in Mice
Shen J, Li J, Wang B, Jin H, Wang M, Zhang Y, Yang Y, Im H, O'Keefe R, Chen D. Deletion of the Transforming Growth Factor β Receptor Type II Gene in Articular Chondrocytes Leads to a Progressive Osteoarthritis‐like Phenotype in Mice. Arthritis & Rheumatism 2013, 65: 3107-3119. PMID: 23982761, PMCID: PMC3928444, DOI: 10.1002/art.38122.Peer-Reviewed Original ResearchMeSH KeywordsADAM ProteinsADAMTS5 ProteinAnimalsCartilage, ArticularChondrocytesCore Binding Factor Alpha 2 SubunitDisease ProgressionMatrix Metalloproteinase 13MiceMice, KnockoutOsteoarthritisPhenotypeProtein Serine-Threonine KinasesReceptor, Transforming Growth Factor-beta Type IIReceptors, Transforming Growth Factor betaSignal TransductionUp-RegulationConceptsCritical downstream target genesDownstream target genesTarget genesGrowth factor β signalingRegulation of Runx2Mouse genetic approachesLoss of TGFβType II geneGene expression analysisInhibition of TGFβDevelopment of osteoarthritisRat chondrosarcoma cellsGenetic approachesExpression analysisConditional knockout miceTGFβ signalingOsteoarthritis-like phenotypeGenesΒ signalingADAMTS5 geneReceptor type IIChondrosarcoma cellsTGFβCartilage homeostasisOA-like phenotype
2011
BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development
Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, Hilton MJ, Wang Y, Chen D. BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. Journal Of Cell Science 2011, 124: 3428-3440. PMID: 21984813, PMCID: PMC3196857, DOI: 10.1242/jcs.083659.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBone DevelopmentBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Cell DifferentiationCell Growth ProcessesCells, CulturedChondrocytesCore Binding Factor Alpha 1 SubunitCyclin-Dependent Kinase 4Gene Expression RegulationGrowth PlateMiceMice, KnockoutOsteochondrodysplasiasProtein Processing, Post-TranslationalSignal TransductionConceptsEndochondral bone developmentBMP4 geneCartilage developmentDeletion of Bmp2Post-transcriptional levelRunx2 protein levelsBone developmentChondrocyte proliferationChondrodysplasia phenotypeProteasomal degradationBMP2 geneGenetic controlKey regulatorConditional knockout miceMolecular mechanismsKnockout miceBMP2Chondrocyte differentiationGenesGrowth plate chondrocytesRunx2 expressionCartilage phenotypeSpecific functionsProfound defectsNovel insights