2023
Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve
Ahmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.Peer-Reviewed Original ResearchConceptsF-NaF PET/CTCalcific aortic valve diseaseBicuspid aortic valvePET/CTAortic valve calcificationAortic valve diseaseAortic valveAortic stenosisValve calcificationValvular calcificationValve diseaseF-NaFSubset of miceTricuspid aortic valveDevelopment of calcificationSignificant correlationUnderwent echocardiographyMedical therapyHigh prevalencePreclinical modelsMurine modelTherapeutic interventionsAge groupsAutoradiography dataMultimodality imaging
2018
Molecular imaging of calcific aortic valve disease
Jung JJ, Jadbabaie F, Sadeghi MM. Molecular imaging of calcific aortic valve disease. Journal Of Nuclear Cardiology 2018, 25: 1148-1155. PMID: 29359271, PMCID: PMC6054901, DOI: 10.1007/s12350-017-1158-7.Peer-Reviewed Original ResearchConceptsCalcific aortic valve diseaseAortic valve diseaseAortic stenosisValve diseaseSymptomatic aortic stenosisProgression of CAVDSubset of patientsRisk of complicationsMolecular imagingAsymptomatic patientsValvular calcificationDisease progressionFluoride PETTherapeutic interventionsClinical settingImaging protocolValvular biologyStenosisPatientsDiseaseCalcificationProgressionImagingEchocardiographyComplications
2016
Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice
Jung JJ, Razavian M, Kim HY, Ye Y, Golestani R, Toczek J, Zhang J, Sadeghi MM. Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice. Scientific Reports 2016, 6: 32659. PMID: 27619752, PMCID: PMC5020643, DOI: 10.1038/srep32659.Peer-Reviewed Original ResearchConceptsCalcific aortic valve diseaseAortic valve diseaseEffect of doxycyclineWestern dietCAVD progressionMatrix metalloproteinasesValve diseaseMicro-single photon emissionNonselective MMP inhibitorTherapeutic blood levelsLack of effectSingle photon emissionMatrix metalloproteinase inhibitorsGroups of animalsAortic stenosisMedical therapyHyperlipidemic miceEarly diseaseBlood levelsCommon causeTissue analysisMMP activationMMP inhibitionGelatinase activityDoxycycline
2015
Multimodality and Molecular Imaging of Matrix Metalloproteinase Activation in Calcific Aortic Valve Disease
Jung JJ, Razavian M, Challa AA, Nie L, Golestani R, Zhang J, Ye Y, Russell KS, Robinson SP, Heistad DD, Sadeghi MM. Multimodality and Molecular Imaging of Matrix Metalloproteinase Activation in Calcific Aortic Valve Disease. Journal Of Nuclear Medicine 2015, 56: 933-938. PMID: 25908827, PMCID: PMC4454445, DOI: 10.2967/jnumed.114.152355.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortic ValveAortic Valve StenosisApolipoproteins EBicuspid Aortic Valve DiseaseCalcinosisDiet, High-FatEchocardiographyHeart Defects, CongenitalHeart Valve DiseasesHumansMatrix MetalloproteinasesMiceMice, TransgenicMolecular ImagingMultimodal ImagingTechnetiumTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsCalcific aortic valve diseaseAortic valve diseaseMatrix metalloproteinasesWestern dietValve diseaseValvular inflammationMMP activityDevelopment of CAVDMedical therapeutic interventionsAortic valve areaSPECT/CT imagesWild-type miceMatrix metalloproteinase activationAortic stenosisMolecular imagingValvular calcificationControl miceCD68 expressionValve areaWD miceDeficient miceCommon causeApolipoprotein ECD68 stainingMurine model
2014
Calcific Aortic Valve Disease
Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific Aortic Valve Disease. Arteriosclerosis Thrombosis And Vascular Biology 2014, 34: 2387-2393. PMID: 25189570, PMCID: PMC4199903, DOI: 10.1161/atvbaha.114.302523.Peer-Reviewed Original ResearchConceptsCalcific aortic valve diseaseAortic valve diseaseValve diseaseSurgical valve replacementNational Heart LungNew therapeutic approachesBasic science researchersValve replacementAortic stenosisSignificant morbidityBlood InstituteTherapeutic optionsPatient populationHeart LungTreatment strategiesTherapeutic approachesDisease processOptimal managementFurther studiesAdditional investigationDiagnostic methodsDiseaseGroupMorbidityStenosis