2024
Abstract 3015: Matrix Metalloproteinase Inhibition In Rat Abdominal Aortic Aneurysm
Zaghloul M, Elizondo-Benedetto S, Arif B, Heo G, Luehmann H, Liu Y, Gropler R, Sadeghi M, Zayed M. Abstract 3015: Matrix Metalloproteinase Inhibition In Rat Abdominal Aortic Aneurysm. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44 DOI: 10.1161/atvb.44.suppl_1.3015.Peer-Reviewed Original ResearchAbdominal aortic aneurysmPostoperative day 3Rupture of abdominal aortic aneurysmsTreated ratsInhibition of matrix metalloproteinasesMatrix metalloproteinase inhibitionMatrix metalloproteinase inhibitorsMatrix metalloproteinasesAortic aneurysmRat modelAbdominal aortic aneurysm diameterUntreated groupMale Sprague-Dawley ratsAbdominal aortic aneurysm rupture rateSprague-Dawley ratsAortic diameter measurementsActive MMP-9Rate of ruptureDegradation of extracellular matrix proteinsAbdominal aortic aneurysm researchIL-17ARadiotracer uptakeUntreated ratsTNF-aIL-1B
2023
Characteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms
Bellamkonda K, Zogg C, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Ochoa Chaar C. Characteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms. Journal Of Vascular Surgery 2023, 77: 1649-1657. PMID: 36796595, DOI: 10.1016/j.jvs.2023.02.003.Peer-Reviewed Original ResearchConceptsEndovascular aneurysm repairAbdominal aortic aneurysmRAAA casesRAAA groupElective repairAneurysm repairAortic aneurysmMyocardial infarctionVascular Quality Initiative databaseLower body mass indexSmall abdominal aortic aneurysmsMean aneurysm diameterVascular Surgery guidelinesLong-term mortalityOutcomes of patientsPerioperative myocardial infarctionOpen AAA repairBody mass indexLong-term outcomesOperative thresholdAfrican AmericansInfrarenal aneurysmsTotal morbidityAAA repairPatient characteristicsHomeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity
Salarian M, Ghim M, Toczek J, Han J, Weiss D, Spronck B, Ramachandra A, Jung J, Kukreja G, Zhang J, Lakheram D, Kim S, Humphrey J, Sadeghi M. Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity. Circulation Research 2023, 132: 432-448. PMID: 36691905, PMCID: PMC9930896, DOI: 10.1161/circresaha.122.322096.Peer-Reviewed Original ResearchConceptsMMP-12 deficiencyAdverse aortic remodelingAbdominal aortic aneurysmAng IIAortic remodelingAortic aneurysmMMP-12Complement component 3 levelsNeutrophil extracellular traps markersAbdominal aortic aneurysm ruptureAortic aneurysm ruptureElastic lamina degradationPlasma complement componentsAortic ruptureC3 levelsComplement depositionPlasma C5aMore neutrophilsVascular remodelingAneurysm ruptureNeutrophil elastaseAortic integrityMatrix metalloproteinaseComplement inhibitorsNETosis pathwayPositron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm
Toczek J, Gona K, Liu Y, Ahmad A, Ghim M, Ojha D, Kukreja G, Salarian M, Luehmann H, Heo G, Guzman R, Chaar C, Tellides G, Hassab A, Ye Y, Shoghi K, Zayed M, Gropler R, Sadeghi M. Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2023, 16: e014615. PMID: 36649454, PMCID: PMC9858355, DOI: 10.1161/circimaging.122.014615.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmHuman aortic tissueMMP activityAortic tissueAortic aneurysmMMP inhibitorsMurine modelMatrix metalloproteinasesPositron emission tomography/Toxicology studiesAortic MMP activityPositron emission tomography radioligandAngiotensin II infusionEmission tomography/Murine abdominal aortic aneurysmsBroad-spectrum MMP inhibitorMatrix metalloproteinase activityPositron emission tomography (PET) tracerPositron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyEmission tomography tracerII infusionRisk stratificationTomography/
2021
Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm
Toczek J, Boodagh P, Sanzida N, Ghim M, Salarian M, Gona K, Kukreja G, Rajendran S, Wei L, Han J, Zhang J, Jung JJ, Graham M, Liu X, Sadeghi MM. Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm. Theranostics 2021, 11: 5876-5888. PMID: 33897887, PMCID: PMC8058712, DOI: 10.7150/thno.55106.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmExiTron nano 12000AAA outcomePhagocytic activityII infusionAng IIAortic aneurysmAortic wall enhancementAng II infusionCT enhancementAngiotensin II infusionRole of inflammationFeasibility of CTMacrophage phagocytic activityNon-invasive toolAAA inductionCD68 expressionModulatory interventionsMacrophage cell lineInflammatory signalsPatient managementVascular pathologyOutcome studiesAdventitial macrophagesComputed tomography
2020
Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging
Gona K, Toczek J, Ye Y, Sanzida N, Golbazi A, Boodagh P, Salarian M, Jung JJ, Rajendran S, Kukreja G, Wu TL, Devel L, Sadeghi MM. Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging. Journal Of Medicinal Chemistry 2020, 63: 15037-15049. PMID: 33206510, PMCID: PMC8010999, DOI: 10.1021/acs.jmedchem.0c01514.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmMMP-12 inhibitorsSelective MMP-12 inhibitorMurine abdominal aortic aneurysmsRadiochemical stabilityFast blood clearanceMolecular imagingAortic aneurysmAAA progressionMMP-12Blood clearanceUpregulated MMPsAortic regionElastase inhibitorLead tracerNovel familyRupture riskMacrophage elastaseInhibitorsSelectivitySpecific bindingSynthesisVivo competitionImagingCharacteristics and Outcomes of Ruptured Abdominal Aortic Aneurysms Below the Size Threshold for Elective Repair
Bellamkonda K, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Chaar C. Characteristics and Outcomes of Ruptured Abdominal Aortic Aneurysms Below the Size Threshold for Elective Repair. Journal Of Vascular Surgery 2020, 72: e289-e290. DOI: 10.1016/j.jvs.2020.06.041.Peer-Reviewed Original ResearchCharacteristics and Outcomes of Ruptured Abdominal Aortic Aneurysms Below the Size Threshold for Elective Repair
Bellamkonda K, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Chaar C. Characteristics and Outcomes of Ruptured Abdominal Aortic Aneurysms Below the Size Threshold for Elective Repair. Journal Of Vascular Surgery 2020, 72: e195-e196. DOI: 10.1016/j.jvs.2020.04.337.Peer-Reviewed Original Research
2019
Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging
Toczek J, Bordenave T, Gona K, Kim HY, Beau F, Georgiadis D, Correia I, Ye Y, Razavian M, Jung J, Lequin O, Dive V, Sadeghi MM, Devel L. Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging. Journal Of Medicinal Chemistry 2019, 62: 9743-9752. PMID: 31603669, PMCID: PMC7054845, DOI: 10.1021/acs.jmedchem.9b01186.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmVascular molecular imagingMurine abdominal aortic aneurysmsMMP-12 gene expressionMatrix metalloproteinase-12Aortic aneurysmInflammatory diseasesAdjacent aortaH postinjectionMMP-12Blood clearanceMetalloproteinase-12Selective radiotracerFurther evaluationMMP-12 inhibitorsMouse bloodHigh uptakeAortaDiseaseMolecular imagingHuman metalloproteasesRadiotracer
2018
Prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population
He BJ, Malm BJ, Carino M, Sadeghi MM. Prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population. Journal Of Nuclear Cardiology 2018, 26: 1688-1693. PMID: 29492838, DOI: 10.1007/s12350-018-1232-9.Peer-Reviewed Original ResearchConceptsIncidental noncardiac findingsMyocardial perfusion imagingNoncardiac findingsPulmonary nodulesIncidental findingActionable incidental findingsVeteran populationOverall interobserver agreementAttenuation correction CTSpecific guidelinesHiatal herniaExtracardiac massPleural plaquesAortic aneurysmPhysician specialtyPerfusion imagingCommon occurringCardiologistsInterobserver agreementInterreader agreementAttenuation artifactsRadiologistsPrevalenceNodulesVeterans
2017
Multi-modality molecular imaging of aortic aneurysms
Malm BJ, Sadeghi MM. Multi-modality molecular imaging of aortic aneurysms. Journal Of Nuclear Cardiology 2017, 24: 1239-1245. PMID: 28447279, PMCID: PMC7720418, DOI: 10.1007/s12350-017-0883-2.BooksConceptsAortic aneurysmMulti-modality molecular imagingMolecular imagingSignificant morbidityAbdominal aortaAneurysm formationAneurysm sizeLower riskAneurysm pathogenesisAneurysmsPotential future roleImaging modalitiesComplicationsDiagnosisImagingMorbidityThrombosisPatientsAortaCurrent gapsFuture rolePathogenesisThoracicMortalityEpidemiology
2016
Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology
Golestani R, Jung JJ, Sadeghi MM. Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology. Journal Of Clinical Medicine 2016, 5: 57. PMID: 27275836, PMCID: PMC4929412, DOI: 10.3390/jcm5060057.Peer-Reviewed Original ResearchVascular remodelingMolecular imaging techniquesPeripheral arterial diseaseSelection of patientsArt molecular imagingImaging techniquesVascular biology researchNuclear imaging techniquesMolecular imagingArterial diseaseRisk stratificationAortic aneurysmMyocardial ischemiaCardiovascular diseaseEarly diagnosisAnimal modelsCardiovascular pathologyTherapeutic interventionsCellular playersClinical toolKey mediatorAngiogenesisRemodelingClinical translationDiseaseNovel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification
Toczek J, Meadows JL, Sadeghi MM. Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification. Circulation Cardiovascular Imaging 2016, 9: e003023. PMID: 26763279, PMCID: PMC4714781, DOI: 10.1161/circimaging.115.003023.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmRisk stratificationAortic aneurysmNovel molecular imaging approachesAbdominal aortic aneurysm repairFluorodeoxyglucose positron emission tomographyAortic aneurysm repairSelection of patientsPatient risk stratificationUltrasmall superparamagnetic particlesMagnetic resonance imagingMolecular imaging approachesAneurysm repairInflammatory cellsClinical trialsPreclinical modelsAneurysm sizeResonance imagingEmission tomographyAneurysm growthMatrix remodelingAneurysmsClinical translationMolecular imagingProteolytic enzymes
2014
Imaging Vessel Wall Biology to Predict Outcome in Abdominal Aortic Aneurysm
Golestani R, Razavian M, Nie L, Zhang J, Jung JJ, Ye Y, de Roo M, Hilgerink K, Liu C, Robinson SP, Sadeghi MM. Imaging Vessel Wall Biology to Predict Outcome in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2014, 8: &na;. PMID: 25550400, PMCID: PMC4284949, DOI: 10.1161/circimaging.114.002471.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticAorta, AbdominalAortic Aneurysm, AbdominalAortic RuptureAortographyBiomarkersDisease Models, AnimalDisease ProgressionEnzyme ActivationFeasibility StudiesMaleMatrix MetalloproteinasesMice, Inbred C57BLMice, TransgenicMolecular ImagingMultimodal ImagingPredictive Value of TestsRadiopharmaceuticalsRisk AssessmentRisk FactorsTime FactorsTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsMicro-single photon emissionAngiotensin IIMatrix metalloproteinasesAortic diameterSuprarenal aortaCD68 expressionMMP activityPotential of MMPSaline-infused miceVessel wall inflammationAbdominal aortic aneurysmPrediction of outcomePhoton emissionRupture riskMurine AAAsAortic expansionRisk stratificationWall inflammationAortic aneurysmSpontaneous ruptureSmall aneurysmsMouse modelControl animalsTracer uptakeAbdominal aortic aneurysm (AAA) rupture riskEmergence of molecular imaging of aortic aneurysm: Implications for risk stratification and management
Golestani R, Sadeghi MM. Emergence of molecular imaging of aortic aneurysm: Implications for risk stratification and management. Journal Of Nuclear Cardiology 2014, 21: 251-267. PMID: 24381115, PMCID: PMC3991015, DOI: 10.1007/s12350-013-9845-5.Peer-Reviewed Original Research