2015
N‐Methyl‐d‐Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers
Krishnan‐Sarin S, O'Malley SS, Franco N, Cavallo DA, Morean M, Shi J, Pittman B, Krystal JH. N‐Methyl‐d‐Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers. Alcohol Clinical And Experimental Research 2015, 39: 300-307. PMID: 25664775, PMCID: PMC4331214, DOI: 10.1111/acer.12619.Peer-Reviewed Original ResearchConceptsAlcohol drinkingFamily historyHeavy drinkersAlcohol cravingN-methyl-D-aspartate receptor antagonistN-methyl-D-aspartate receptor antagonismAlcohol cue-induced cravingEffects of FHHigher baseline levelsPresence of impulsivityAlcohol use disorderCue-induced cravingAlcohol-induced stimulationReceptor antagonismReceptor antagonistPriming doseNMDA receptorsUse disordersMemantineBaseline levelsModulatory influencePotential efficacyAlcohol accessDrinkersEighth day
2012
Human Laboratory Paradigms in Alcohol Research
Plebani J, Ray L, Morean M, Corbin W, MacKillop J, Amlung M, King A. Human Laboratory Paradigms in Alcohol Research. Alcohol Clinical And Experimental Research 2012, 36: 972-983. PMID: 22309888, PMCID: PMC4167612, DOI: 10.1111/j.1530-0277.2011.01704.x.Peer-Reviewed Original ResearchConceptsHuman laboratory studiesAlcohol cravingAlcohol researchHuman laboratory paradigmsMechanisms of riskField of alcoholAlcohol phenotypesNeurobehavioral mechanismsAlcohol pharmacotherapyLaboratory paradigmAlcohol effectsExperimental laboratory approachAlcohol riskNeuropharmacological effectsMedication developmentPhenotype refinementTranslational phenotypesAlcohol usersCravingTreatment responsePhenotypically distinct subtypesFindings to studiesAlcoholAlcoholic etiologyBehavioral economics