Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosis
Stewart RM, Rodriguez EC, King MC. Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosis. Molecular Biology Of The Cell 2019, 30: 1664-1675. PMID: 31091167, PMCID: PMC6727752, DOI: 10.1091/mbc.e18-07-0438.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCardiomegalyCell AdhesionCell Nucleus ShapeDNA-Binding ProteinsFibrosisGene DeletionIntegrinsMAP Kinase Signaling SystemMembrane ProteinsMice, Inbred C57BLMice, KnockoutMultiprotein ComplexesMyocardiumNuclear EnvelopeProto-Oncogene Proteins c-aktSarcomeresTelomere-Binding ProteinsTransforming Growth Factor betaConceptsLINC complexType laminsInner nuclear membrane protein MAN1Nuclear envelopeA-type laminsSarcomeric contractile apparatusNuclear laminaDisease etiologyProfibrotic signalingCytoskeletal linkageAKT/MAPK signalingCardiomyocyte cytoskeletonPlasma membraneMAPK signalingNegative regulatorAntagonistic rolesTGFβ signalingLaminsCellular adhesionSignalingCardiac hypertrophySUN2Human cardiomyopathyHypertrophy markersContractile apparatus