2023
An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
Ader N, Chen L, Surovtsev I, Chadwick W, Rodriguez E, King M, Lusk C. An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity. Nature Cell Biology 2023, 25: 1465-1477. PMID: 37783794, PMCID: PMC11365527, DOI: 10.1038/s41556-023-01235-4.Peer-Reviewed Original ResearchConceptsSpindle pole body proteinNuclear envelope barrierESCRT-III proteinsNuclear pore complexSpindle pole bodyNucleocytoplasmic compartmentalizationESCRT functionPore complexPole bodyDistinct complementNuclear compartmentNuclear integrityTransport proteinsMolecular mechanismsRemodelling mechanismProteinBody protein
2014
The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body
Wälde S, King MC. The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body. Journal Of Cell Science 2014, 127: 3625-3640. PMID: 24963130, PMCID: PMC4132395, DOI: 10.1242/jcs.154997.Peer-Reviewed Original ResearchConceptsSpindle pole bodyMitotic entryPole bodySUN domain protein Sad1Nuclear envelopeMitotic spindle pole bodiesPolo kinase Plo1SUN-KASH complexesYeast centrosome equivalentBipolar spindle formationCentrosome equivalentMitotic remodelingSchizosaccharomyces pombeSpindle formationSpindle polesMonopolar spindlesMitotic catastrophePlo1Cut12PCP1KMS2Sad1PombeBiogenesisRemodeling