2014
A Role for Nuclear Envelope Bridging Complexes in Homology-Directed Repair
Swartz RK, Rodriguez EC, King MC. A Role for Nuclear Envelope Bridging Complexes in Homology-Directed Repair. Molecular Biology Of The Cell 2014, 25: mbc.e13-10-0569. PMID: 24943839, PMCID: PMC4142617, DOI: 10.1091/mbc.e13-10-0569.Peer-Reviewed Original ResearchConceptsDNA double-strand breaksHomology-directed repairRepair of DSBsNumber of genesDouble-strand breaksSame gene productCytoskeleton (LINC) complexLINC complexGenome instabilityATR kinaseGene conversionKms1DSB resectionGene productsDepolymerization of microtubulesCell cycleCytoplasmic microtubulesG2 phaseDNA damageSad1MicrotubulesComplexesNucleoskeletonMTO1CytoskeletonThe KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body
Wälde S, King MC. The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body. Journal Of Cell Science 2014, 127: 3625-3640. PMID: 24963130, PMCID: PMC4132395, DOI: 10.1242/jcs.154997.Peer-Reviewed Original ResearchConceptsSpindle pole bodyMitotic entryPole bodySUN domain protein Sad1Nuclear envelopeMitotic spindle pole bodiesPolo kinase Plo1SUN-KASH complexesYeast centrosome equivalentBipolar spindle formationCentrosome equivalentMitotic remodelingSchizosaccharomyces pombeSpindle formationSpindle polesMonopolar spindlesMitotic catastrophePlo1Cut12PCP1KMS2Sad1PombeBiogenesisRemodeling
2008
A Network of Nuclear Envelope Membrane Proteins Linking Centromeres to Microtubules
King MC, Drivas TG, Blobel G. A Network of Nuclear Envelope Membrane Proteins Linking Centromeres to Microtubules. Cell 2008, 134: 427-438. PMID: 18692466, PMCID: PMC2617791, DOI: 10.1016/j.cell.2008.06.022.Peer-Reviewed Original ResearchConceptsSUN-KASH complexesNuclear membrane proteinsMembrane proteinsIntegral inner nuclear membrane proteinsSUN domain protein Sad1Nuclear envelopeSpindle pole body componentInner nuclear membrane proteinFission yeast S. pombeOuter nuclear membrane proteinsCytoplasmic microtubulesYeast S. pombeMicrotubule-dependent forcesNuclear envelope membranesCentromeric DNAS. pombeCentromeric heterochromatinHeterochromatic regionsEnvelope membraneIMA1MicrotubulesSad1HeterochromatinProteinNuclear heterochromatin