2018
Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease
Stewart R, King M, Horsley V. Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease. Stem Cell Biology And Regenerative Medicine 2018, 263-292. DOI: 10.1007/978-3-319-16769-5_11.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNuclear laminaIntegral inner nuclear membrane proteinsInner nuclear membrane proteinSkin developmentMechanical signalsNuclear membrane proteinsInner nuclear membraneIntegration of biochemicalGenome integrityNuclear peripheryTranscriptional outputNuclear laminsAssociated chromatinMembrane proteinsNuclear interiorTissue-level mechanicsGene expressionNuclear membraneSkin homeostasisKeratinocyte differentiationMechanical inputChromatinLaminsLaminaProteinThe Molecular Composition and Function of the Nuclear Periphery and Its Impact on the Genome
Lusk C, King M. The Molecular Composition and Function of the Nuclear Periphery and Its Impact on the Genome. 2018, 35-62. DOI: 10.1007/978-3-319-71614-5_2.Peer-Reviewed Original ResearchNuclear peripheryNuclear subcompartmentsIntegral inner nuclear membrane proteinsInner nuclear membrane proteinSpecific genic regionsRepressive histone marksNuclear membrane proteinsGene-poor chromatinModern genomic analysesGenome stabilityHistone marksNuclear architectureGenic regionsTranscriptional outputNuclear laminsGene positionMembrane proteinsGenomic analysisDevelopmental inputsMolecular insightsMolecular componentsGenomeModel systemMolecular compositionCurrent understanding
2008
A Network of Nuclear Envelope Membrane Proteins Linking Centromeres to Microtubules
King MC, Drivas TG, Blobel G. A Network of Nuclear Envelope Membrane Proteins Linking Centromeres to Microtubules. Cell 2008, 134: 427-438. PMID: 18692466, PMCID: PMC2617791, DOI: 10.1016/j.cell.2008.06.022.Peer-Reviewed Original ResearchConceptsSUN-KASH complexesNuclear membrane proteinsMembrane proteinsIntegral inner nuclear membrane proteinsSUN domain protein Sad1Nuclear envelopeSpindle pole body componentInner nuclear membrane proteinFission yeast S. pombeOuter nuclear membrane proteinsCytoplasmic microtubulesYeast S. pombeMicrotubule-dependent forcesNuclear envelope membranesCentromeric DNAS. pombeCentromeric heterochromatinHeterochromatic regionsEnvelope membraneIMA1MicrotubulesSad1HeterochromatinProteinNuclear heterochromatin
2006
Karyopherin-mediated import of integral inner nuclear membrane proteins
King MC, Lusk C, Blobel G. Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 2006, 442: 1003-1007. PMID: 16929305, DOI: 10.1038/nature05075.Peer-Reviewed Original ResearchConceptsIntegral membrane proteinsInner nuclear membraneINM proteinsMembrane proteinsIntegral inner nuclear membrane proteinsInner nuclear membrane proteinNuclear pore complex proteinsNuclear membrane proteinsRan GTPase cycleBasic sequence motifsNuclear localization signalNuclear pore complexPore complex proteinsAppropriate cellular compartmentDiscrete sequence elementsINM targetingLocalization signalPore complexGTPase cycleNuclear transportSequence motifsCellular compartmentsComplex proteinsSequence elementsKaryopherin β1