Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction
Wu M, Dumalska I, Morozova E, van den Pol A, Alreja M. Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 17217-17222. PMID: 19805188, PMCID: PMC2761345, DOI: 10.1073/pnas.0908200106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainEnergy MetabolismFemaleGonadotropin-Releasing HormoneGreen Fluorescent ProteinsHypothalamic HormonesImmunohistochemistryKisspeptinsMaleMelaninsMembrane PotentialsMiceMice, TransgenicMicroscopy, FluorescenceNeuronsPatch-Clamp TechniquesPeptide FragmentsPituitary HormonesReceptors, SomatostatinReproductionTime FactorsTumor Suppressor ProteinsVesicular Glutamate Transport Protein 2ConceptsInhibitory effectDirect postsynaptic effectGnRH-GFP neuronsMCH knockout miceMCH-immunoreactive fibersRole of MCHMelanin-concentrating hormone (MCH) systemMCH receptor antagonistsPatch-clamp recordingsMelanin-concentrating hormoneNegative energy balanceKisspeptin activationDrug abuse behaviorGnRH neuronsPostsynaptic effectsExcitatory effectsGABAergic neuronsTransgenic GFP miceImmunoreactive fibersReceptor antagonistCNS neuronsAntidepressant drugsBrain slicesFood restrictionKnockout mice