The comprehensive midtrimester test: High-sensitivity down syndrome test
Bahado-Singh R, Shahabi S, Karaca M, Mahoney MJ, Cole L, Oz UA. The comprehensive midtrimester test: High-sensitivity down syndrome test. American Journal Of Obstetrics And Gynecology 2002, 186: 803-808. PMID: 11967511, DOI: 10.1067/mob.2002.121651.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsAlpha-FetoproteinsAmniocentesisChorionic GonadotropinChorionic Gonadotropin, beta Subunit, HumanDown SyndromeEstriolFalse Positive ReactionsFemaleGestational AgeHumansNeckPregnancyPregnancy Trimester, SecondPrenatal DiagnosisSensitivity and SpecificityUltrasonography, PrenatalConceptsDown syndrome casesDown syndrome detectionMaternal ageSyndrome casesSyndrome detectionStepwise logistic regression analysisReceiver-operating characteristic curveBeta-core fragmentAdvanced maternal ageLogistic regression analysisDown syndrome riskLow-risk screeningFalse positive rateDifferent age groupsGestational ageLarge trialsSignificant markersSyndrome riskStudy groupNuchal thicknessClinical valueUltrasound biometryGenetic amniocentesisSmall studySonographic anomalies