2024
Flaviviruses manipulate mitochondrial processes to evade the innate immune response
Boytz R, Keita K, Pawlak J, Laurent-Rolle M. Flaviviruses manipulate mitochondrial processes to evade the innate immune response. Npj Viruses 2024, 2: 47. PMID: 39371935, PMCID: PMC11452341, DOI: 10.1038/s44298-024-00057-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMitochondrial processesAntiviral signaling proteinProgrammed cell deathRegulate various aspectsInnate immune response to viral infectionEukaryotic organellesResponse to viral infectionMitochondrial biologyInnate immune responseMitochondrial morphologyCellular processesSignaling proteinsCell deathImmune response to viral infectionInnate immunityMitochondriaCalcium homeostasisFlavivirusesViral infectionImmune responseOrganellesPathogensDynamic structureProteinHomeostasis
2022
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication
Hsu JC, Laurent-Rolle M, Pawlak JB, Xia H, Kunte A, Hee JS, Lim J, Harris LD, Wood JM, Evans GB, Shi PY, Grove TL, Almo SC, Cresswell P. Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication. Molecular Cell 2022, 82: 1631-1642.e6. PMID: 35316659, PMCID: PMC9081181, DOI: 10.1016/j.molcel.2022.02.031.Peer-Reviewed Original ResearchConceptsInterferon-stimulated genesS-adenosyl methionineTranslation inhibitionRadical S-adenosyl methionineInnate immune responseIntegrated stress response pathwayStress response pathwaysViral RNA translationImmune responseAntiviral responseInnate immunityAntiviral mechanismTranslation regulatorsTranslational repressionViral replicationEnzymatic productDidehydro-CTPResponse pathwaysRNA translationViperinSAM activityPathwayInhibitionBroad spectrumReplication
2021
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein
Hsu JC, Laurent-Rolle M, Pawlak JB, Wilen CB, Cresswell P. Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2101161118. PMID: 34045361, PMCID: PMC8214666, DOI: 10.1073/pnas.2101161118.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Interferon-stimulated genesImmune responseSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Host protein synthesisRespiratory syndrome coronavirus 2Syndrome coronavirus 2Innate immune responseUnprecedented global health crisisCoronavirus 2N7-methyltransferase activityOngoing COVID-19 pandemicHuman coronavirusesTranslational shutdownVirus replicationNsp14 proteinGlobal health crisisProtein synthesisInhibition activityCausative agentCOVID-19COVID-19 pandemicSARS-CoV-2 nsp14Dependent induction
2015
La Piedad Michoacán Mexico Virus V protein antagonizes type I interferon response by binding STAT2 protein and preventing STATs nuclear translocation
Pisanelli G, Laurent-Rolle M, Manicassamy B, Belicha-Villanueva A, Morrison J, Lozano-Dubernard B, Castro-Peralta F, Iovane G, García-Sastre. A. La Piedad Michoacán Mexico Virus V protein antagonizes type I interferon response by binding STAT2 protein and preventing STATs nuclear translocation. Virus Research 2015, 213: 11-22. PMID: 26546155, PMCID: PMC5538256, DOI: 10.1016/j.virusres.2015.10.027.Peer-Reviewed Original ResearchConceptsNuclear translocationParamyxoviridae familyIFN α/βSTAT2 proteinRubulavirus genusMost paramyxovirusesV proteinType I interferon responseI interferon responseCellular responsesSTAT2Innate immune responseAmino acidsType I interferonSignificant disease burdenProteinBlue eye diseaseMexico virusInterferon responseProtein levelsSwine cellsIFN responseSTAT1I interferonRespiratory distress
2009
NS5 of Dengue Virus Mediates STAT2 Binding and Degradation
Ashour J, Laurent-Rolle M, Shi PY, García-Sastre A. NS5 of Dengue Virus Mediates STAT2 Binding and Degradation. Journal Of Virology 2009, 83: 5408-5418. PMID: 19279106, PMCID: PMC2681973, DOI: 10.1128/jvi.02188-08.Peer-Reviewed Original ResearchConceptsDengue virusInnate immune responseInnate antiviral responseImmune responseInfection resultsIFN responseAntiviral responseDENV proteinsLevel of expressionAntiviral therapeuticsDENV genomeDecreased levelsInterferonPotential targetProtein levelsViral pathogensHost proteasesReduced levelsProteasome activityMultiple mechanismsVirusFacilitate infectionNovel mechanismViral polypeptidesNS5