Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis
Vasanthakumar A, Lepore JB, Zegarek MH, Kocherginsky M, Singh M, Davis EM, Link PA, Anastasi J, Le Beau MM, Karpf AR, Godley LA. Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis. Blood 2013, 121: 2059-2063. PMID: 23315164, PMCID: PMC3596965, DOI: 10.1182/blood-2012-04-421065.Peer-Reviewed Original ResearchConceptsHaploinsufficient tumor suppressor geneTumor suppressor geneDNA methylationDe novo DNA methyltransferasesSuppressor geneNovo DNA methyltransferasesExpression of DNMT3B7Abnormal DNA methylationDominant negative isoformDifferent molecular mechanismsDNMT3B isoformsDNA methyltransferasesDNA hypermethylationDNMT3B geneAberrant splicingMolecular mechanismsTumor suppressorAbnormal transcriptsMYC/Human cancersGenesDNMT3B7DNMT3BMethylationMYC