2013
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis
Vasanthakumar A, Lepore JB, Zegarek MH, Kocherginsky M, Singh M, Davis EM, Link PA, Anastasi J, Le Beau MM, Karpf AR, Godley LA. Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis. Blood 2013, 121: 2059-2063. PMID: 23315164, PMCID: PMC3596965, DOI: 10.1182/blood-2012-04-421065.Peer-Reviewed Original ResearchConceptsHaploinsufficient tumor suppressor geneTumor suppressor geneDNA methylationDe novo DNA methyltransferasesSuppressor geneNovo DNA methyltransferasesExpression of DNMT3B7Abnormal DNA methylationDominant negative isoformDifferent molecular mechanismsDNMT3B isoformsDNA methyltransferasesDNA hypermethylationDNMT3B geneAberrant splicingMolecular mechanismsTumor suppressorAbnormal transcriptsMYC/Human cancersGenesDNMT3B7DNMT3BMethylationMYC
2011
Myc-Mediated Lymphomagenesis Is Driven by DNA Methylation Changes Induced by DNMT3B7 Expression and Dnmt3b Heterozygosity
Vasanthakumar A, Lepore J, Zegarek M, Kocherginsky M, Singh M, Godley L. Myc-Mediated Lymphomagenesis Is Driven by DNA Methylation Changes Induced by DNMT3B7 Expression and Dnmt3b Heterozygosity. Blood 2011, 118: 225. DOI: 10.1182/blood.v118.21.225.225.Peer-Reviewed Original ResearchEμ-myc miceDNA methylationGlobal DNA hypermethylationDNA hypermethylationMyc bindsDNA methyltransferasesE-boxDNA methyltransferasePromoter regionCancer cellsDnmt3a/bDNA methylation patternsChromatin immunoprecipitation analysisDNA methylation changesTranscription start siteCo-immunoprecipitation studiesAbnormal DNA methylationBinding of MYCGlobal DNA methylationTransformation of cellsDominant negative isoformNon-transformed cellsDNMT3B isoformsPremature stop codonEukaryotic cells