Myc-Mediated Lymphomagenesis Is Driven by DNA Methylation Changes Induced by DNMT3B7 Expression and Dnmt3b Heterozygosity
Vasanthakumar A, Lepore J, Zegarek M, Kocherginsky M, Singh M, Godley L. Myc-Mediated Lymphomagenesis Is Driven by DNA Methylation Changes Induced by DNMT3B7 Expression and Dnmt3b Heterozygosity. Blood 2011, 118: 225. DOI: 10.1182/blood.v118.21.225.225.Peer-Reviewed Original ResearchEμ-myc miceDNA methylationGlobal DNA hypermethylationDNA hypermethylationMyc bindsDNA methyltransferasesE-boxDNA methyltransferasePromoter regionCancer cellsDnmt3a/bDNA methylation patternsChromatin immunoprecipitation analysisDNA methylation changesTranscription start siteCo-immunoprecipitation studiesAbnormal DNA methylationBinding of MYCGlobal DNA methylationTransformation of cellsDominant negative isoformNon-transformed cellsDNMT3B isoformsPremature stop codonEukaryotic cells