2024
Hospital Readmissions Among Infants With Neonatal Opioid Withdrawal Syndrome
Gaither J, Drago M, Grossman M, Li Y, Shabanova V, Xu X, Leventhal J. Hospital Readmissions Among Infants With Neonatal Opioid Withdrawal Syndrome. JAMA Network Open 2024, 7: e2435074. PMID: 39316398, PMCID: PMC11423163, DOI: 10.1001/jamanetworkopen.2024.35074.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidCross-Sectional StudiesFemaleHumansInfant, NewbornMaleNeonatal Abstinence SyndromeOpioid-Related DisordersPatient ReadmissionRetrospective StudiesUnited StatesConceptsNeonatal opioid withdrawal syndromeOpioid withdrawal syndromeWithdrawal syndromeCohort studyHospital readmissionLow birth weightReadmission ratesRetrospective cohort studyIncreased risk of readmissionNationwide Readmissions DatabaseClinical Modification codesGestational ageOdds of readmissionMultiple gestationsFull-termInternational Classification of DiseasesRisk of readmissionHospital discharge recordsBirth weightSurvey-weighted logistic regressionType of insuranceIncreased 5-foldIncreased riskReadmissions DatabaseYear of birth
2022
Early Weight Loss Percentile Curves and Feeding Practices in Opioid-Exposed Infants.
Cheng FY, Shabanova V, Berkwitt AK, Grossman MR. Early Weight Loss Percentile Curves and Feeding Practices in Opioid-Exposed Infants. Hospital Pediatrics 2022, 12: 857-866. PMID: 36073203, DOI: 10.1542/hpeds.2021-006137.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBirth WeightFemaleGestational AgeHumansInfantInfant, NewbornNeonatal Abstinence SyndromePregnancyWeight LossConceptsNeonatal opioid withdrawal syndromeFeeding practicesWeight loss patternsBirth weightMedian percent weight lossWeight lossMean gestational ageOpioid withdrawal syndromeMean birth weightPercentile curvesRisk of morbidityHours of lifeHealth care useConfidence intervalsOptimal feeding methodNonpharmacologic treatmentsPharmacologic treatmentWithdrawal syndromeGestational agePercent weight lossSingle centerCare useInclusion criteriaInfantsDelivery typeDoes Maternal Incarceration Impact Infants with Neonatal Abstinence Syndrome?
Drago MJ, Shabanova V, Hochreiter D, Grossman M, Mercurio M. Does Maternal Incarceration Impact Infants with Neonatal Abstinence Syndrome? Maternal And Child Health Journal 2022, 26: 1095-1103. PMID: 35088297, DOI: 10.1007/s10995-021-03356-4.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidFemaleHumansInfant, NewbornLength of StayMorphineNeonatal Abstinence SyndromeOpioid-Related DisordersPregnancyRetrospective StudiesConceptsNeonatal abstinence syndromeLength of stayNon-incarcerated womenLine agentsAbstinence syndromeBreast milkMean LOSLonger LOSIncarcerated womenRetrospective cohort studyFirst-line agentsMaternal-infant dyadsSecond-line agentsPrenatal substance exposurePrenatal alcohol useCare of infantsCohort studyFinnegan scoreInfant dischargeLonger hospitalizationSubstance exposureInfantsPoisson regressionMaternal incarcerationAlcohol use
2021
Parent Perspectives on the Eat, Sleep, Console Approach for the Care of Opioid-Exposed Infants
McRae K, Sebastian T, Grossman M, Loyal J. Parent Perspectives on the Eat, Sleep, Console Approach for the Care of Opioid-Exposed Infants. Hospital Pediatrics 2021, 11: 358-365. PMID: 33658244, DOI: 10.1542/hpeds.2020-002139.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidHumansInfantInfant, NewbornLength of StayNeonatal Abstinence SyndromeParentsSleepConceptsNeonatal abstinence syndromeTreatment of infantsParents of infantsNonpharmacologic interventionsNewborn careAbstinence syndromeInfant HospitalMost infantsInpatient unitExpectant mothersInfantsFunction-based assessmentOverall positive experienceHospitalExperiences of parentsMost participantsCareFeelings of guiltSemistructured interviewsSleepParents' perspectivesEmotional supportInterventionEATHypothesis-driven approach
2020
Evaluating the effect of hospital setting on outcomes for neonatal abstinence syndrome
Grossman MR, Berkwitt AK, Osborn RR, Citarella BV, Hochreiter D, Bizzarro MJ. Evaluating the effect of hospital setting on outcomes for neonatal abstinence syndrome. Journal Of Perinatology 2020, 40: 1483-1488. PMID: 32086436, DOI: 10.1038/s41372-020-0621-5.Peer-Reviewed Original ResearchMeSH KeywordsHospitalsHumansInfant, NewbornIntensive Care Units, NeonatalLength of StayMorphineNeonatal Abstinence SyndromeRetrospective StudiesConceptsNeonatal abstinence syndromeLength of stayAbstinence syndromeInpatient groupNICU groupCombination groupHospital costsInpatient unitGeneral inpatient floorEffect of hospitalImpact of hospitalDifferent hospital unitsMorphine treatmentSecondary outcomesPrimary outcomeBreastfeeding ratesRetrospective studyStudy designWeInpatient floorHospital unitsStayNICUSyndromeHospitalOutcomesRacial association and pharmacotherapy in neonatal opioid withdrawal syndrome: thinking beyond genetics
Grossman MR, Berkwitt AK, Osborn RR. Racial association and pharmacotherapy in neonatal opioid withdrawal syndrome: thinking beyond genetics. Journal Of Perinatology 2020, 40: 689-690. PMID: 32076112, DOI: 10.1038/s41372-020-0607-3.Peer-Reviewed Original Research
2019
Neonatal abstinence syndrome
Grossman M, Berkwitt A. Neonatal abstinence syndrome. Seminars In Perinatology 2019, 43: 173-186. PMID: 30773241, DOI: 10.1053/j.semperi.2019.01.007.Peer-Reviewed Original ResearchMeSH KeywordsBreast FeedingComplementary TherapiesDirective CounselingHumansInfant, NewbornLength of StayMothersNeonatal Abstinence SyndromeOpiate Substitution TreatmentPatient ParticipationRooming-in CareConceptsNeonatal abstinence syndromeAbstinence syndromeIncidence of NASScoring toolNon-pharmacologic interventionsDoses of medicationLong-term outcomesCare of infantsHospital stayMedication usageWithdrawal signsHealthcare systemSyndromeInfantsIncidenceCareScreening approachMedicationsOpioidsRoomingNeonatesStayPathophysiologyDoses
2018
A Novel Approach to Assessing Infants With Neonatal Abstinence Syndrome
Grossman MR, Lipshaw MJ, Osborn RR, Berkwitt AK. A Novel Approach to Assessing Infants With Neonatal Abstinence Syndrome. Hospital Pediatrics 2018, 8: 1-6. PMID: 29263121, DOI: 10.1542/hpeds.2017-0128.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidClinical Decision-MakingFemaleHumansInfant CareInfant, NewbornMaleMorphineNeonatal Abstinence SyndromeRetrospective StudiesConceptsNeonatal abstinence syndromeManagement of infantsTreatment decisionsAbstinence syndromeYale-New Haven Children's HospitalOpioid-exposed infantsLength of stayActual treatment decisionsHealth care systemOpioid treatmentAdverse eventsPharmacologic treatmentPrimary outcomeChildren's HospitalPostnatal treatmentInpatient unitSignificant burdenMorphineInfantsCare systemSyndromeHospitalTreatmentScoresDays
2017
An Initiative to Improve the Quality of Care of Infants With Neonatal Abstinence Syndrome
Grossman MR, Berkwitt AK, Osborn RR, Xu Y, Esserman DA, Shapiro ED, Bizzarro MJ. An Initiative to Improve the Quality of Care of Infants With Neonatal Abstinence Syndrome. Pediatrics 2017, 139: e20163360. PMID: 28562267, PMCID: PMC5470506, DOI: 10.1542/peds.2016-3360.Peer-Reviewed Original ResearchConceptsNeonatal abstinence syndromeAdverse eventsAbstinence syndromeHospital costsYale-New Haven Children's HospitalTreatment of NASMethadone-exposed infantsLonger hospital stayProportion of infantsAdministration of morphineTransfer of infantsStudy-Act cyclesQuality of careMusculoskeletal disturbancesNonpharmacologic careNonpharmacologic therapiesHospital stayMorphine useOpioid withdrawalChildren's HospitalPostimplementation periodSustained decreaseOutcome measuresInpatient unitMultidisciplinary teamNeonatal Abstinence Syndrome: Time for a Reappraisal
Grossman MR, Osborn RR, Berkwitt AK. Neonatal Abstinence Syndrome: Time for a Reappraisal. Hospital Pediatrics 2017, 7: 115-116. PMID: 28137921, DOI: 10.1542/hpeds.2016-0119.Peer-Reviewed Original Research