2022
Does Maternal Incarceration Impact Infants with Neonatal Abstinence Syndrome?
Drago MJ, Shabanova V, Hochreiter D, Grossman M, Mercurio M. Does Maternal Incarceration Impact Infants with Neonatal Abstinence Syndrome? Maternal And Child Health Journal 2022, 26: 1095-1103. PMID: 35088297, DOI: 10.1007/s10995-021-03356-4.Peer-Reviewed Original ResearchConceptsNeonatal abstinence syndromeLength of stayNon-incarcerated womenLine agentsAbstinence syndromeBreast milkMean LOSLonger LOSIncarcerated womenRetrospective cohort studyFirst-line agentsMaternal-infant dyadsSecond-line agentsPrenatal substance exposurePrenatal alcohol useCare of infantsCohort studyFinnegan scoreInfant dischargeLonger hospitalizationSubstance exposureInfantsPoisson regressionMaternal incarcerationAlcohol use
2021
Neonatal Abstinence Syndrome: Management Advances and Therapeutic Approaches
Cheng F, McMillan C, Morrison A, Berkwitt A, Grossman M. Neonatal Abstinence Syndrome: Management Advances and Therapeutic Approaches. Current Addiction Reports 2021, 8: 595-604. DOI: 10.1007/s40429-021-00387-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNeonatal abstinence syndromeMaternal-infant dyadsNon-pharmacologic interventionsNumber of infantsDevelopment of NASOpioid crisisLong-term neurodevelopmental outcomesNon-pharmacologic careOpioid-exposed infantsProportion of infantsLength of stayPurpose of ReviewInBirth hospitalizationOutpatient managementInpatient managementNeurodevelopmental outcomesClinical presentationAbstinence syndromeVulnerable infantsPharmacologic agentsStrategy warrantsClinical pathwayTherapeutic approachesFunctional assessmentInfantsParent Perspectives on the Eat, Sleep, Console Approach for the Care of Opioid-Exposed Infants
McRae K, Sebastian T, Grossman M, Loyal J. Parent Perspectives on the Eat, Sleep, Console Approach for the Care of Opioid-Exposed Infants. Hospital Pediatrics 2021, 11: 358-365. PMID: 33658244, DOI: 10.1542/hpeds.2020-002139.Peer-Reviewed Original ResearchConceptsNeonatal abstinence syndromeTreatment of infantsParents of infantsNonpharmacologic interventionsNewborn careAbstinence syndromeInfant HospitalMost infantsInpatient unitExpectant mothersInfantsFunction-based assessmentOverall positive experienceHospitalExperiences of parentsMost participantsCareFeelings of guiltSemistructured interviewsSleepParents' perspectivesEmotional supportInterventionEATHypothesis-driven approach
2020
Evaluating the effect of hospital setting on outcomes for neonatal abstinence syndrome
Grossman MR, Berkwitt AK, Osborn RR, Citarella BV, Hochreiter D, Bizzarro MJ. Evaluating the effect of hospital setting on outcomes for neonatal abstinence syndrome. Journal Of Perinatology 2020, 40: 1483-1488. PMID: 32086436, DOI: 10.1038/s41372-020-0621-5.Peer-Reviewed Original ResearchConceptsNeonatal abstinence syndromeLength of stayAbstinence syndromeInpatient groupNICU groupCombination groupHospital costsInpatient unitGeneral inpatient floorEffect of hospitalImpact of hospitalDifferent hospital unitsMorphine treatmentSecondary outcomesPrimary outcomeBreastfeeding ratesRetrospective studyStudy designWeInpatient floorHospital unitsStayNICUSyndromeHospitalOutcomes
2019
Neonatal abstinence syndrome
Grossman M, Berkwitt A. Neonatal abstinence syndrome. Seminars In Perinatology 2019, 43: 173-186. PMID: 30773241, DOI: 10.1053/j.semperi.2019.01.007.Peer-Reviewed Original ResearchConceptsNeonatal abstinence syndromeAbstinence syndromeIncidence of NASScoring toolNon-pharmacologic interventionsDoses of medicationLong-term outcomesCare of infantsHospital stayMedication usageWithdrawal signsHealthcare systemSyndromeInfantsIncidenceCareScreening approachMedicationsOpioidsRoomingNeonatesStayPathophysiologyDoses
2018
A Novel Approach to Assessing Infants With Neonatal Abstinence Syndrome
Grossman MR, Lipshaw MJ, Osborn RR, Berkwitt AK. A Novel Approach to Assessing Infants With Neonatal Abstinence Syndrome. Hospital Pediatrics 2018, 8: 1-6. PMID: 29263121, DOI: 10.1542/hpeds.2017-0128.Peer-Reviewed Original ResearchConceptsNeonatal abstinence syndromeManagement of infantsTreatment decisionsAbstinence syndromeYale-New Haven Children's HospitalOpioid-exposed infantsLength of stayActual treatment decisionsHealth care systemOpioid treatmentAdverse eventsPharmacologic treatmentPrimary outcomeChildren's HospitalPostnatal treatmentInpatient unitSignificant burdenMorphineInfantsCare systemSyndromeHospitalTreatmentScoresDays
2017
An Initiative to Improve the Quality of Care of Infants With Neonatal Abstinence Syndrome
Grossman MR, Berkwitt AK, Osborn RR, Xu Y, Esserman DA, Shapiro ED, Bizzarro MJ. An Initiative to Improve the Quality of Care of Infants With Neonatal Abstinence Syndrome. Pediatrics 2017, 139: e20163360. PMID: 28562267, PMCID: PMC5470506, DOI: 10.1542/peds.2016-3360.Peer-Reviewed Original ResearchConceptsNeonatal abstinence syndromeAdverse eventsAbstinence syndromeHospital costsYale-New Haven Children's HospitalTreatment of NASMethadone-exposed infantsLonger hospital stayProportion of infantsAdministration of morphineTransfer of infantsStudy-Act cyclesQuality of careMusculoskeletal disturbancesNonpharmacologic careNonpharmacologic therapiesHospital stayMorphine useOpioid withdrawalChildren's HospitalPostimplementation periodSustained decreaseOutcome measuresInpatient unitMultidisciplinary team