2018
Digital Polymerase Chain Reaction Quantification of SERPINA1 Predicts Prognosis in High-Grade Glioma
Ookawa S, Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, Oka S, Ohtaki S, Noshiro S, Komatsu K, Akiyama Y, Mikami T, Mikuni N, Kocsis JD, Honmou O. Digital Polymerase Chain Reaction Quantification of SERPINA1 Predicts Prognosis in High-Grade Glioma. World Neurosurgery 2018, 111: e783-e789. PMID: 29309973, DOI: 10.1016/j.wneu.2017.12.166.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasExpression of SERPINA1Polymerase chain reactionDigital polymerase chain reactionExpression groupMedian overall survivalAnti-inflammatory roleHigh expression groupMessenger RNA expressionCell linesGlioblastoma multiforme cell linesHuman glioblastoma cell linesParaffin-embedded tissuesPredict PrognosisOverall survivalPoor prognosisGrade IIIPolymerase chain reaction quantificationSERPINA1 expressionSurgical samplesGrade IVImmunohistochemical analysisGlioblastoma cell linesGlioma tissuesPrognosis
2017
Interleukin-13 receptor alpha 2 as a marker of poorer prognosis in high-grade astrocytomas.
Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, Oka S, Otsuka Y, Yamaguchi M, Ohnishi H, Ohtaki S, Noshiro S, Ookawa S, Mikami T, Mikuni N, Honmou O. Interleukin-13 receptor alpha 2 as a marker of poorer prognosis in high-grade astrocytomas. Journal Of Neurosurgical Sciences 2017, 62: 239-244. PMID: 28079349, DOI: 10.23736/s0390-5616.16.03793-0.Peer-Reviewed Original ResearchConceptsHigh-grade astrocytomasInterleukin-13 receptor alpha 2Overall survivalMIB-1 indexReceptor alpha 2Median OSPoor prognosisPatient ageCox proportional hazards modelWorld Health Organization gradeMedian overall survivalMedian survival benefitAdvanced patient ageAlpha 2Real-time quantitative reverse transcription polymerase chain reactionLow expression groupQuantitative reverse transcription polymerase chain reactionReverse transcription-polymerase chain reactionProportional hazards modelTranscription-polymerase chain reactionExpression levelsSubset of casesParaffin-embedded glioma samplesHazard ratioSurvival benefit
2016
Double balloon protection during carotid artery stenting for vulnerable carotid stenosis reduces the incidence of new brain lesions
Nakazaki M, Nonaka T, Takahashi A, Yonemasu Y, Nomura T, Onda T, Honda O, Hashimoto Y, Ohnishi H, Sasaki M, Daibo M, Honmou O. Double balloon protection during carotid artery stenting for vulnerable carotid stenosis reduces the incidence of new brain lesions. Acta Neurochirurgica 2016, 158: 1377-1386. PMID: 27138330, DOI: 10.1007/s00701-016-2816-2.Peer-Reviewed Original ResearchConceptsDouble balloon protectionCarotid artery stentingDistal balloon protectionDistal filter protectionBalloon protectionCarotid stenosisNew lesionsFilter protectionDistal protectionDiffusion-weighted imaging studiesNew brain lesionsProximal balloon occlusionResultsSixty-four patientsIndependent significant factorsPosterior cervical musclesLogistic regression analysisT1-weighted imagesIschemic complicationsEmbolic complicationsArtery stentingBalloon occlusionCervical musclesDWI findingsTarget lesionsOdds ratio