2022
The Impact of Purple-Flesh Potato (Solanum tuberosum L.) cv. “Shadow Queen” on Minor Health Complaints in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study
Maeda-Yamamoto M, Honmou O, Sasaki M, Haseda A, Kagami-Katsuyama H, Shoji T, Namioka A, Namioka T, Magota H, Oka S, Kataoka-Sasaki Y, Ukai R, Takemura M, Nishihira J. The Impact of Purple-Flesh Potato (Solanum tuberosum L.) cv. “Shadow Queen” on Minor Health Complaints in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients 2022, 14: 2446. PMID: 35745176, PMCID: PMC9227939, DOI: 10.3390/nu14122446.Peer-Reviewed Original ResearchConceptsMinor health complaintsHealth complaintsHealthy adultsMesenchymal stem cellsMSC countPlacebo groupWeeks 0Psychological stress responsesHealthy subjectsIntake periodStress responseAdverse effectsComplaintsTest groupStem cellsStudy determinesAdultsGroupCountPurple potatoesResponsePlaceboIrritabilityIntakeIngestion
2021
Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case series
Honmou O, Yamashita T, Morita T, Oshigiri T, Hirota R, Iyama S, Kato J, Sasaki Y, Ishiai S, Ito YM, Namioka A, Namioka T, Nakazaki M, Kataoka-Sasaki Y, Onodera R, Oka S, Sasaki M, Waxman SG, Kocsis JD. Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case series. Clinical Neurology And Neurosurgery 2021, 203: 106565. PMID: 33667953, DOI: 10.1016/j.clineuro.2021.106565.Peer-Reviewed Original ResearchConceptsSpinal cord injuryAmerican Spinal Injury Association Impairment ScaleMSC infusionAutologous mesenchymal stem cellsASIA CASIA DIntravenous infusionMesenchymal stem cellsSCI patientsFunctional statusFunctional improvementSpinal cord injury patientsSpinal Cord Independence MeasureASIA B patientsASIA C patientsPhase 2 studySerious adverse eventsCord injury patientsCurrent therapeutic optionsStem cellsASIA BASIA gradeC patientsNeurologic improvementAdverse events
2018
Digital Polymerase Chain Reaction Quantification of SERPINA1 Predicts Prognosis in High-Grade Glioma
Ookawa S, Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, Oka S, Ohtaki S, Noshiro S, Komatsu K, Akiyama Y, Mikami T, Mikuni N, Kocsis JD, Honmou O. Digital Polymerase Chain Reaction Quantification of SERPINA1 Predicts Prognosis in High-Grade Glioma. World Neurosurgery 2018, 111: e783-e789. PMID: 29309973, DOI: 10.1016/j.wneu.2017.12.166.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasExpression of SERPINA1Polymerase chain reactionDigital polymerase chain reactionExpression groupMedian overall survivalAnti-inflammatory roleHigh expression groupMessenger RNA expressionCell linesGlioblastoma multiforme cell linesHuman glioblastoma cell linesParaffin-embedded tissuesPredict PrognosisOverall survivalPoor prognosisGrade IIIPolymerase chain reaction quantificationSERPINA1 expressionSurgical samplesGrade IVImmunohistochemical analysisGlioblastoma cell linesGlioma tissuesPrognosis
2017
Cerebral aneurysm neck diameter is an independent predictor of progressive occlusion after stent-assisted coiling
Nakazaki M, Nonaka T, Nomura T, Onda T, Yonemasu Y, Takahashi A, Hashimoto Y, Honda O, Oka S, Sasaki M, Daibo M, Honmou O. Cerebral aneurysm neck diameter is an independent predictor of progressive occlusion after stent-assisted coiling. Acta Neurochirurgica 2017, 159: 1313-1319. PMID: 28488070, DOI: 10.1007/s00701-017-3199-8.Peer-Reviewed Original ResearchConceptsStent-assisted coilingProgressive occlusionIndependent predictorsOcclusion gradeNeck diameterNeuroform stentsMultivariate logistic regression analysisMultivariate logistic regression modelCurve analysisAneurysm neck diameterMean volume embolization ratioLogistic regression analysisCharacteristic curve analysisROC curve analysisLogistic regression modelsMedian neck diameterResidual aneurysmUnivariate analysisOdds ratioVolume embolization ratioAneurysmsCerebral aneurysmsInterleukin-13 receptor alpha 2 as a marker of poorer prognosis in high-grade astrocytomas.
Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, Oka S, Otsuka Y, Yamaguchi M, Ohnishi H, Ohtaki S, Noshiro S, Ookawa S, Mikami T, Mikuni N, Honmou O. Interleukin-13 receptor alpha 2 as a marker of poorer prognosis in high-grade astrocytomas. Journal Of Neurosurgical Sciences 2017, 62: 239-244. PMID: 28079349, DOI: 10.23736/s0390-5616.16.03793-0.Peer-Reviewed Original ResearchConceptsHigh-grade astrocytomasInterleukin-13 receptor alpha 2Overall survivalMIB-1 indexReceptor alpha 2Median OSPoor prognosisPatient ageCox proportional hazards modelWorld Health Organization gradeMedian overall survivalMedian survival benefitAdvanced patient ageAlpha 2Real-time quantitative reverse transcription polymerase chain reactionLow expression groupQuantitative reverse transcription polymerase chain reactionReverse transcription-polymerase chain reactionProportional hazards modelTranscription-polymerase chain reactionExpression levelsSubset of casesParaffin-embedded glioma samplesHazard ratioSurvival benefitCo-expression of tissue factor and IL-6 in immature endothelial cells of cerebral cavernous malformations
Noshiro S, Mikami T, Kataoka-Sasaki Y, Sasaki M, Ohnishi H, Ohtaki S, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O. Co-expression of tissue factor and IL-6 in immature endothelial cells of cerebral cavernous malformations. Journal Of Clinical Neuroscience 2017, 37: 83-90. PMID: 28087183, DOI: 10.1016/j.jocn.2016.12.023.Peer-Reviewed Original ResearchConceptsCerebral cavernous malformationsInterleukin-6Immature endothelial cellsTissue factorMRNA expression levelsEndothelial cellsCavernous malformationsSporadic cerebral cavernous malformationDistribution of TFExpression levelsNormal endothelial cellsClinical factorsPrognostic rolePathological findingsUnderlying pathologyOperative specimensMRNA expressionAssociation of TFAbnormal clustersMalformationsProgressive eventsMessenger RNACellsExpressionAssociation
2016
Double balloon protection during carotid artery stenting for vulnerable carotid stenosis reduces the incidence of new brain lesions
Nakazaki M, Nonaka T, Takahashi A, Yonemasu Y, Nomura T, Onda T, Honda O, Hashimoto Y, Ohnishi H, Sasaki M, Daibo M, Honmou O. Double balloon protection during carotid artery stenting for vulnerable carotid stenosis reduces the incidence of new brain lesions. Acta Neurochirurgica 2016, 158: 1377-1386. PMID: 27138330, DOI: 10.1007/s00701-016-2816-2.Peer-Reviewed Original ResearchConceptsDouble balloon protectionCarotid artery stentingDistal balloon protectionDistal filter protectionBalloon protectionCarotid stenosisNew lesionsFilter protectionDistal protectionDiffusion-weighted imaging studiesNew brain lesionsProximal balloon occlusionResultsSixty-four patientsIndependent significant factorsPosterior cervical musclesLogistic regression analysisT1-weighted imagesIschemic complicationsEmbolic complicationsArtery stentingBalloon occlusionCervical musclesDWI findingsTarget lesionsOdds ratioACTC1 as an invasion and prognosis marker in glioma.
Ohtaki S, Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, Oka S, Noshiro S, Akiyama Y, Mikami T, Mikuni N, Kocsis JD, Honmou O. ACTC1 as an invasion and prognosis marker in glioma. Journal Of Neurosurgery 2016, 126: 467-475. PMID: 27081897, DOI: 10.3171/2016.1.jns152075.Peer-Reviewed Original ResearchConceptsMedian overall survivalKarnofsky Performance Scale statusTime of diagnosisMIB-1 indexGBM patientsHazard ratioPatient ageRadiological findingsKaplan-Meier methodHigh-grade gliomasReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionRemote recurrenceDistant recurrenceOverall survivalClinical featuresIndependent prognosticRecurrence rateWHO criteriaGrade IIIPolymerase chain reactionSurgical removalContralateral cerebralGrade IGrade II