2020
“Chronic” State in Neural Diseases as the Target of Cellular Therapy with Mesenchymal Stem Cells
Sasaki M, Oka S, Kataoka-Sasaki Y, Kocsis JD, Honmou O. “Chronic” State in Neural Diseases as the Target of Cellular Therapy with Mesenchymal Stem Cells. World Neurosurgery 2020, 135: 375-376. PMID: 32143241, DOI: 10.1016/j.wneu.2019.12.137.Peer-Reviewed Original Research
2016
Intravenous infusion of mesenchymal stem cells promotes functional recovery in a model of chronic spinal cord injury
Morita T, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Oka S, Oshigiri T, Takebayashi T, Yamashita T, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells promotes functional recovery in a model of chronic spinal cord injury. Neuroscience 2016, 335: 221-231. PMID: 27586052, DOI: 10.1016/j.neuroscience.2016.08.037.Peer-Reviewed Original ResearchConceptsSpinal cord injuryIntravenous infusionMesenchymal stem cellsCord injuryBone marrowBlood-spinal cord barrier integrityPhases of SCIChronic spinal cord injuryOpen-field locomotor functionContusive spinal cord injurySevere Contusive Spinal Cord InjuryVehicle-treated groupStem cellsAdult bone marrowBSCB leakageMSC infusionExtensive remyelinationMotor recoveryFunctional recoverySerotonergic fibersCorticospinal tractSystemic infusionFunctional improvementSpinal cordRat model