2021
Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis
Magota H, Sasaki M, Kataoka-Sasaki Y, Oka S, Ukai R, Kiyose R, Onodera R, Kocsis JD, Honmou O. Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis. Molecular Brain 2021, 14: 76. PMID: 33962678, PMCID: PMC8103621, DOI: 10.1186/s13041-021-00787-6.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisAdministration of MSCsSingle infusionMesenchymal stem cellsMotor functionGait abilityDisease progressionMotor neuronsRat modelLateral sclerosisBlood-spinal cord barrierSOD1G93A rat modelSpinal cord degenerateVehicle infusion groupHind limb functionALS rat modelStem cellsLimb functionVehicle infusionFatal disorderSurvival periodTherapeutic effectLocomotor activityInfusionProgressive deteriorationIntravenous infusion of mesenchymal stem cells delays disease progression in the SOD1G93A transgenic amyotrophic lateral sclerosis rat model
Magota H, Sasaki M, Kataoka-Sasaki Y, Oka S, Ukai R, Kiyose R, Onodera R, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells delays disease progression in the SOD1G93A transgenic amyotrophic lateral sclerosis rat model. Brain Research 2021, 1757: 147296. PMID: 33516815, DOI: 10.1016/j.brainres.2021.147296.Peer-Reviewed Original ResearchConceptsBlood-spinal cord barrierQuantitative reverse transcription polymerase chain reactionIntravenous infusionDisease progressionMotor neuronsMSC groupLocomotor functionOpen-field locomotor functionPreservation of microvasculatureHind limb functionCommon clinical featuresEvans blue leakageMotor neuron lossReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionDevastating neurodegenerative diseaseBBB scoringBSCB functionRotarod testingClinical featuresNeuron lossLimb functionNeurotrophic factorCurative strategiesSpinal cord
2018
Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus
Fukumura S, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Nagahama H, Morita T, Sakai T, Tsutsumi H, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus. Epilepsy Research 2018, 141: 56-63. PMID: 29475054, DOI: 10.1016/j.eplepsyres.2018.02.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalGlutamate DecarboxylaseGreen Fluorescent ProteinsHippocampusInfusions, IntravenousLithiumMagnetic Resonance ImagingMaleMaze LearningMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMuscarinic AgonistsNeuronsPhosphopyruvate HydratasePilocarpineRatsRats, Sprague-DawleyRats, TransgenicStatus EpilepticusTime FactorsConceptsAberrant mossy fiber sproutingMossy fiber sproutingStatus epilepticusNeuronal cell deathMesenchymal stem cellsMSC infusionIntravenous infusionRat modelCognitive functionMorris water maze testCognitive function preservationNumber of GAD67Water maze testVehicle-infused ratsMagnetic resonance imagingCell deathStem cellsSeizure frequencyFiber sproutingFunction preservationTimm stainingMaze testHippocampal neuronsImmunohistochemical stainingCognitive deterioration
2015
Diffuse and persistent blood–spinal cord barrier disruption after contusive spinal cord injury rapidly recovers following intravenous infusion of bone marrow mesenchymal stem cells
Matsushita T, Lankford KL, Arroyo EJ, Sasaki M, Neyazi M, Radtke C, Kocsis JD. Diffuse and persistent blood–spinal cord barrier disruption after contusive spinal cord injury rapidly recovers following intravenous infusion of bone marrow mesenchymal stem cells. Experimental Neurology 2015, 267: 152-164. PMID: 25771801, DOI: 10.1016/j.expneurol.2015.03.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBlood-Brain BarrierCell- and Tissue-Based TherapyDisease Models, AnimalEndothelial CellsExploratory BehaviorGlial Fibrillary Acidic ProteinLocomotionMaleMesenchymal Stem CellsMicrovesselsPermeabilityRatsRats, Sprague-DawleyRats, TransgenicReceptor, Platelet-Derived Growth Factor betaSpinal Cord InjuriesTime FactorsVon Willebrand FactorConceptsSpinal cord injuryContusive spinal cord injuryBlood-spinal cord barrierBSCB leakageIntravenous infusionMesenchymal stem cellsVon Willebrand factorMSC infusionCord injurySpinal cordBlood-spinal cord barrier disruptionExperimental spinal cord injuryIntravenous MSC infusionSpinal cord barrierEx vivo optical imagingDissociation of pericytesBone marrow mesenchymal stem cellsStem cellsMarrow mesenchymal stem cellsBSCB integrityBSCB permeabilityLocomotor recoveryPost-SCIBarrier disruptionAntigen expression
2009
Convergence of Cells from the Progenitor Fraction of Adult Olfactory Bulb Tissue to Remyelinating Glia in Demyelinating Spinal Cord Lesions
Markakis EA, Sasaki M, Lankford KL, Kocsis JD. Convergence of Cells from the Progenitor Fraction of Adult Olfactory Bulb Tissue to Remyelinating Glia in Demyelinating Spinal Cord Lesions. PLOS ONE 2009, 4: e7260. PMID: 19787061, PMCID: PMC2747269, DOI: 10.1371/journal.pone.0007260.Peer-Reviewed Original Research
2008
Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X‐irradiated spinal cord not shared by Schwann cells
Lankford KL, Sasaki M, Radtke C, Kocsis JD. Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X‐irradiated spinal cord not shared by Schwann cells. Glia 2008, 56: 1664-1678. PMID: 18551623, DOI: 10.1002/glia.20718.Peer-Reviewed Original ResearchConceptsCentral nervous systemSpinal cordSchwann cellsOligodendrocyte progenitor cellsNormal central nervous systemMigratory propertiesOX-42 stainingNormal spinal cordOlfactory Ensheathing CellsMyelin-forming cellsDemyelinated lesionsHost axonsPhagocytic phenotypePoor survivalSubsequent lesionsNervous systemWhite matterCordLimited survivalOECsMigratory capabilityProgenitor cellsTransplantationX-irradiationLesions