2017
Detection of vulnerable neurons damaged by environmental insults in utero
Torii M, Sasaki M, Chang YW, Ishii S, Waxman SG, Kocsis JD, Rakic P, Hashimoto-Torii K. Detection of vulnerable neurons damaged by environmental insults in utero. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 2367-2372. PMID: 28123061, PMCID: PMC5338500, DOI: 10.1073/pnas.1620641114.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexElectroporationEmbryo, MammalianEthanolFemaleFlow CytometryGene Expression RegulationGenes, ReporterHeat Shock Transcription FactorsHeat-Shock ResponseLuminescent ProteinsMiceMice, TransgenicNeuronsNicotinePlasmidsPregnancyPrenatal Exposure Delayed EffectsResponse ElementsSuraminConceptsTransgenic reporter miceHeat shock factor 1 (HSF1) activationPrenatal exposureVulnerable neuronsPrognostic biomarkerReporter miceSusceptible individualsPostnatal disordersPostnatal lifeMultiple disordersNeuronsReporter assaysCellular damageEnvironmental insultsMiceHarmful agentsDisordersExposureTreatmentPhysical agentsFluorescence reporter systemPathogenesisSymptomsUteroAgents
2012
Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model
Suzuki J, Sasaki M, Harada K, Bando M, Kataoka Y, Onodera R, Mikami T, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O. Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model. Brain Research 2012, 1497: 15-22. PMID: 23274536, DOI: 10.1016/j.brainres.2012.12.028.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain InfarctionCerebral CortexDisease Models, AnimalExercise TestImage Processing, Computer-AssistedInfarction, Middle Cerebral ArteryMagnetic Resonance ImagingMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMovement DisordersOxygenRatsRats, Sprague-DawleyStatistics, NonparametricTime FactorsConceptsMSC groupMesenchymal stem cellsLesion volumeFunctional MRISensorimotor cortexMotor functionElectrical stimulationRat cerebral infarction modelGreater functional recoveryCerebral infarction modelImproved motor functionImproved functional outcomesRat stroke modelHigh-intensity signalStem cellsFunctional recoveryBilateral signalsCortical hyperactivityFunctional outcomeIntravenous infusionIntravenous transplantationFunctional deficitsSomatosensory cortexInfused groupStroke model