2022
Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model
Maeda S, Kawamura T, Sasaki M, Shimamura K, Shibuya T, Harada A, Honmou O, Sawa Y, Miyagawa S. Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. Scientific Reports 2022, 12: 16986. PMID: 36216855, PMCID: PMC9551049, DOI: 10.1038/s41598-022-18485-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone MarrowDisease Models, AnimalGreen Fluorescent ProteinsHindlimbInfusions, IntravenousIschemiaLower ExtremityMesenchymal Stem Cell TransplantationMesenchymal Stem CellsNeovascularization, PhysiologicPerfusionPeripheral Vascular DiseasesRatsRats, Sprague-DawleyVascular Endothelial Growth Factor AConceptsIntravenous infusionVascular endothelial growth factorMesenchymal stem cellsTissue perfusionHindlimb ischemia modelRat hindlimb ischemia modelIschemia modelCell groupsFemoral artery removalIschemia animal modelStem cellsHindlimb muscle tissueBone marrow-derived mesenchymal stem cellsEndothelial growth factorMarrow-derived mesenchymal stem cellsMSC infusionHistological findingsIschemic limbsHindlimb ischemiaCell delivery methodsIschemic hindlimbSprague-DawleyCapillary densityAnimal modelsInfusion
2018
Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus
Fukumura S, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Nagahama H, Morita T, Sakai T, Tsutsumi H, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus. Epilepsy Research 2018, 141: 56-63. PMID: 29475054, DOI: 10.1016/j.eplepsyres.2018.02.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalGlutamate DecarboxylaseGreen Fluorescent ProteinsHippocampusInfusions, IntravenousLithiumMagnetic Resonance ImagingMaleMaze LearningMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMuscarinic AgonistsNeuronsPhosphopyruvate HydratasePilocarpineRatsRats, Sprague-DawleyRats, TransgenicStatus EpilepticusTime FactorsConceptsAberrant mossy fiber sproutingMossy fiber sproutingStatus epilepticusNeuronal cell deathMesenchymal stem cellsMSC infusionIntravenous infusionRat modelCognitive functionMorris water maze testCognitive function preservationNumber of GAD67Water maze testVehicle-infused ratsMagnetic resonance imagingCell deathStem cellsSeizure frequencyFiber sproutingFunction preservationTimm stainingMaze testHippocampal neuronsImmunohistochemical stainingCognitive deterioration
2013
Olfactory ensheathing cells, but not schwann cells, proliferate and migrate extensively within moderately X‐Irradiated juvenile rat brain
Lankford KL, Brown RJ, Sasaki M, Kocsis JD. Olfactory ensheathing cells, but not schwann cells, proliferate and migrate extensively within moderately X‐Irradiated juvenile rat brain. Glia 2013, 62: 52-63. PMID: 24166823, DOI: 10.1002/glia.22583.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntigensCD11b AntigenCell MovementCell ProliferationCells, CulturedFemaleGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsMaleNeurogliaOlfactory MucosaOligodendrogliaProteoglycansRadiation Injuries, ExperimentalRatsRats, Sprague-DawleySchwann CellsStem Cell TransplantationConceptsJuvenile rat brainAdult spinal cordIntact adult spinal cordSchwann cellsSpinal cordRat brainAdult rat spinal cordSpinal cord lesionsRat spinal cordCord lesionsModerate radiation doseNeuronal repairPoor survivalAdult CNSUnbiased stereologyCordOECsBrainThree weeksNumber of cellsRadiation dosePermissive environmentCell migrationCellsMicroglia
2011
CNPase Expression in Olfactory Ensheathing Cells
Radtke C, Sasaki M, Lankford KL, Gallo V, Kocsis JD. CNPase Expression in Olfactory Ensheathing Cells. BioMed Research International 2011, 2011: 608496. PMID: 22174557, PMCID: PMC3228405, DOI: 10.1155/2011/608496.Peer-Reviewed Original ResearchConceptsOuter nerve layerOlfactory bulbNerve layerPeripheral nervesCNPase expressionOlfactory nerve axonsTransplantation of OECsSpinal cord injuryEndogenous Schwann cellsExpression of CNPaseTransplantation of olfactoryOlfactory Ensheathing CellsEnhanced green fluorescent proteinMyelination potentialCord injuryAxonal regenerationRegenerated axonsSchwann cellsTransgenic miceNerve axonsPeripheral myelinNerveCNPaseMyelinOECs
2009
Convergence of Cells from the Progenitor Fraction of Adult Olfactory Bulb Tissue to Remyelinating Glia in Demyelinating Spinal Cord Lesions
Markakis EA, Sasaki M, Lankford KL, Kocsis JD. Convergence of Cells from the Progenitor Fraction of Adult Olfactory Bulb Tissue to Remyelinating Glia in Demyelinating Spinal Cord Lesions. PLOS ONE 2009, 4: e7260. PMID: 19787061, PMCID: PMC2747269, DOI: 10.1371/journal.pone.0007260.Peer-Reviewed Original Research
2006
Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells
Dombrowski MA, Sasaki M, Lankford KL, Kocsis JD, Radtke C. Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells. Brain Research 2006, 1125: 1-8. PMID: 17112480, PMCID: PMC2673087, DOI: 10.1016/j.brainres.2006.09.089.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCell Adhesion Molecules, NeuronalCell TransplantationGreen Fluorescent ProteinsImmunohistochemistryMicroscopy, ImmunoelectronMyelin SheathNAV1.6 Voltage-Gated Sodium ChannelNerve RegenerationNeurofilament ProteinsNeurogliaOlfactory BulbRanvier's NodesRatsRats, Sprague-DawleySciatic NeuropathySodium ChannelsTime FactorsConceptsPeripheral nerve fibersPeripheral nervesNodes of RanvierFunctional outcomeAxonal regenerationNerve fibersRegenerated peripheral nerve fibersSciatic nerve crush lesionNerve crush lesionPeripheral-type myelinSpinal cord resultsTransplantation of olfactoryPeripheral axonal regenerationParanodal CasprCrush lesionCord resultsFunctional improvementOlfactory bulbTransection siteTransgenic ratsLesion zoneNerveNodal formationTransplantation siteOECs
2004
Identified Olfactory Ensheathing Cells Transplanted into the Transected Dorsal Funiculus Bridge the Lesion and Form Myelin
Sasaki M, Lankford KL, Zemedkun M, Kocsis JD. Identified Olfactory Ensheathing Cells Transplanted into the Transected Dorsal Funiculus Bridge the Lesion and Form Myelin. Journal Of Neuroscience 2004, 24: 8485-8493. PMID: 15456822, PMCID: PMC2605369, DOI: 10.1523/jneurosci.1998-04.2004.Peer-Reviewed Original ResearchConceptsSprague-DawleyOlfactory bulbTransection siteMyelinated axonsLesion zoneForm myelinOpen field locomotor behaviorAdult olfactory bulbTransection lesionTransplantation groupPattern of repairSD ratsSpinal cordLesion areaLesionsCellular elementsImproved locomotionAxonsLocomotor behaviorMyelinGFP cellsGreen fluorescent proteinCellsAnti-GFP antibodyDiscrete bundles