2013
Olfactory ensheathing cells, but not schwann cells, proliferate and migrate extensively within moderately X‐Irradiated juvenile rat brain
Lankford KL, Brown RJ, Sasaki M, Kocsis JD. Olfactory ensheathing cells, but not schwann cells, proliferate and migrate extensively within moderately X‐Irradiated juvenile rat brain. Glia 2013, 62: 52-63. PMID: 24166823, DOI: 10.1002/glia.22583.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntigensCD11b AntigenCell MovementCell ProliferationCells, CulturedFemaleGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsMaleNeurogliaOlfactory MucosaOligodendrogliaProteoglycansRadiation Injuries, ExperimentalRatsRats, Sprague-DawleySchwann CellsStem Cell TransplantationConceptsJuvenile rat brainAdult spinal cordIntact adult spinal cordSchwann cellsSpinal cordRat brainAdult rat spinal cordSpinal cord lesionsRat spinal cordCord lesionsModerate radiation doseNeuronal repairPoor survivalAdult CNSUnbiased stereologyCordOECsBrainThree weeksNumber of cellsRadiation dosePermissive environmentCell migrationCellsMicroglia
2011
CNPase Expression in Olfactory Ensheathing Cells
Radtke C, Sasaki M, Lankford KL, Gallo V, Kocsis JD. CNPase Expression in Olfactory Ensheathing Cells. BioMed Research International 2011, 2011: 608496. PMID: 22174557, PMCID: PMC3228405, DOI: 10.1155/2011/608496.Peer-Reviewed Original ResearchConceptsOuter nerve layerOlfactory bulbNerve layerPeripheral nervesCNPase expressionOlfactory nerve axonsTransplantation of OECsSpinal cord injuryEndogenous Schwann cellsExpression of CNPaseTransplantation of olfactoryOlfactory Ensheathing CellsEnhanced green fluorescent proteinMyelination potentialCord injuryAxonal regenerationRegenerated axonsSchwann cellsTransgenic miceNerve axonsPeripheral myelinNerveCNPaseMyelinOECs
2008
Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X‐irradiated spinal cord not shared by Schwann cells
Lankford KL, Sasaki M, Radtke C, Kocsis JD. Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X‐irradiated spinal cord not shared by Schwann cells. Glia 2008, 56: 1664-1678. PMID: 18551623, DOI: 10.1002/glia.20718.Peer-Reviewed Original ResearchConceptsCentral nervous systemSpinal cordSchwann cellsOligodendrocyte progenitor cellsNormal central nervous systemMigratory propertiesOX-42 stainingNormal spinal cordOlfactory Ensheathing CellsMyelin-forming cellsDemyelinated lesionsHost axonsPhagocytic phenotypePoor survivalSubsequent lesionsNervous systemWhite matterCordLimited survivalOECsMigratory capabilityProgenitor cellsTransplantationX-irradiationLesions
2000
[Remyelination by Schwann cell transplantation for CNS demyelinated axons: functional comparison with developmental myelination].
Imaizumi T, Tsushima S, Sasaki M, Akiyama Y, Hashi K. [Remyelination by Schwann cell transplantation for CNS demyelinated axons: functional comparison with developmental myelination]. Brain And Nerve 脳と神経 2000, 52: 701-7. PMID: 11002480.Peer-Reviewed Original ResearchConceptsCompound action potentialConduction velocitySC transplantationAdult ratsDemyelinated axonsHigh-frequency stimulationDay old pupsLower conduction velocityNormal adult ratsSC myelinationSpinal cordFrequency stimulationRat dorsalHistological examinationStimulus trainsTransplantationOld pupsRemyelinationAmplitude decrementAction potentialsNormal adultsAxonsRatsNormal DCsMyelination[Comparison of myelin-forming cells as candidates for therapeutic transplantation in demyelinated CNS axons].
Imaizumi T, Lankford K, Kocsis J, Sasaki M, Akiyama Y, Hashi K. [Comparison of myelin-forming cells as candidates for therapeutic transplantation in demyelinated CNS axons]. Brain And Nerve 脳と神経 2000, 52: 609-15. PMID: 10934721.Peer-Reviewed Original ResearchConceptsDemyelinated CNS axonsSchwann cellsBrain cellsSpinal cordConduction velocityCNS axonsAdult rat spinal cordFronto-temporal lobesRat spinal cordAdult Schwann cellsDemyelination of axonsMyelin-forming cellsBlock of conductionAdult olfactoryDemyelinated diseasesDemyelinated axonsLess myelinationHistological examinationCNS tissueTherapeutic approachesStimulus trainsDay 28Transplanted OECsAmplitude decrementRemyelination