2017
Mesenchymal Stem Cells
Sasaki M, Honmou O. Mesenchymal Stem Cells. 2017, 147-156. DOI: 10.1007/978-4-431-56059-3_12.Peer-Reviewed Original ResearchIntravenous infusionMesenchymal stem cellsAdult human bone marrowHuman bone marrowAnimal modelsBone marrowInfused mesenchymal stem cellsHuman stroke patientsSpinal cord injuryInitial clinical studiesInitial human studiesStem cellsAxonal sproutingCerebral strokeStroke patientsCord injuryFunctional improvementClinical studiesTherapeutic effectStroke modelHuman studiesInfusionStrokeMarrowHuman mesenchymal stem cells
2016
Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats
Sasaki Y, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Suzuki J, Tateyama D, Oka S, Namioka T, Namioka A, Onodera R, Mikami T, Wanibuchi M, Kakizawa M, Ishiai S, Kocsis JD, Honmou O. Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats. Physical Therapy 2016, 96: 1791-1798. PMID: 27174259, DOI: 10.2522/ptj.20150504.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery occlusionIntravenous infusionDaily rehabilitationMesenchymal stem cellsMSC infusionFunctional outcomePermanent middle cerebral artery occlusionLimb placement testCerebral artery occlusionRat stroke modelRat MCAO modelIntraluminal vascular occlusionMagnetic resonance imagingStem cellsAdult bone marrowArtery occlusionCerebral ischemiaMCAO modelVascular occlusionFunctional improvementLesion volumeTherapy groupTherapeutic effectStroke modelGroup 2
2012
Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model
Suzuki J, Sasaki M, Harada K, Bando M, Kataoka Y, Onodera R, Mikami T, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O. Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model. Brain Research 2012, 1497: 15-22. PMID: 23274536, DOI: 10.1016/j.brainres.2012.12.028.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain InfarctionCerebral CortexDisease Models, AnimalExercise TestImage Processing, Computer-AssistedInfarction, Middle Cerebral ArteryMagnetic Resonance ImagingMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMovement DisordersOxygenRatsRats, Sprague-DawleyStatistics, NonparametricTime FactorsConceptsMSC groupMesenchymal stem cellsLesion volumeFunctional MRISensorimotor cortexMotor functionElectrical stimulationRat cerebral infarction modelGreater functional recoveryCerebral infarction modelImproved motor functionImproved functional outcomesRat stroke modelHigh-intensity signalStem cellsFunctional recoveryBilateral signalsCortical hyperactivityFunctional outcomeIntravenous infusionIntravenous transplantationFunctional deficitsSomatosensory cortexInfused groupStroke modelMesenchymal stem cells: therapeutic outlook for stroke
Honmou O, Onodera R, Sasaki M, Waxman SG, Kocsis JD. Mesenchymal stem cells: therapeutic outlook for stroke. Trends In Molecular Medicine 2012, 18: 292-297. PMID: 22459358, DOI: 10.1016/j.molmed.2012.02.003.Peer-Reviewed Original ResearchConceptsMarrow-derived mesenchymal stem cellsTransplanted MSCsSpinal cord injuryInitial clinical studiesInitial human studiesBone marrow-derived mesenchymal stem cellsAdult bone marrow-derived mesenchymal stem cellsAdult human bone marrowAxonal sproutingCerebral ischemiaClinical outcomesNeuroprotective effectsCord injuryHuman bone marrowClinical studiesTherapeutic effectStroke modelAnimal modelsHuman studiesBone marrowMesenchymal stem cellsIntravenous deliveryTherapeutic outlookMSC deliveryStroke
2009
Development of a stroke model in the nonhuman primate and a safety study of IV infusion of human mesenchymal stem cells
Sasaki M, Radtke C, Honmou O, Houkin K, Kocsis J. Development of a stroke model in the nonhuman primate and a safety study of IV infusion of human mesenchymal stem cells. Neuroscience Research 2009, 65: s127. DOI: 10.1016/j.neures.2009.09.613.Peer-Reviewed Original Research
2002
Transplantation of human neural stem cells into the stroke model
Honmou O, Oka S, Sasaki M, Takahashi A, Tanooka A, Houkin K, Hashi K. Transplantation of human neural stem cells into the stroke model. Nosotchu 2002, 24: 355. DOI: 10.3995/jstroke.24.355.Peer-Reviewed Original ResearchHuman neural stem cellsNeural stem cellsStroke modelNeural stem cell transplantationStem cellsStem cell transplantationAdult mammalian brainExperimental animal modelsPossible therapeutic strategiesNeural productionIschemic lesionsIschemic volumeCell transplantationHistological examinationAdult brainTherapeutic strategiesAnimal modelsTransplantationGlial lineagesMammalian brainCell therapyFunctional benefitsMultipotential propertiesPresent reportStroke