2021
Focal brainstem infarction in the adult rat
Namioka A, Namioka T, Sasaki M, Kocsis JD, Honmou O. Focal brainstem infarction in the adult rat. Lab Animal 2021, 50: 97-107. PMID: 33564191, DOI: 10.1038/s41684-021-00722-1.Peer-Reviewed Original ResearchConceptsBrainstem ischemiaNew therapeutic approachesIschemic lesionsFunctional recoveryTherapeutic approachesAnimal modelsFemale Sprague-Dawley ratsBrainstem ischemic lesionsLower basilar arteryArtery occlusion modelIschemic lesion volumeType of strokeReliable animal modelSprague-Dawley ratsBrainstem infarctionExtended observation periodNeurological deficitsBasilar arteryLesion volumeOcclusion modelAdult ratsIschemiaPresent symptomsSurvival rateHigher survival rate
2008
Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injury
Radtke C, Sasaki M, Lankford KL, Vogt PM, Kocsis JD. Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injury. The Journal Of Rehabilitation Research And Development 2008, 45: 141-152. PMID: 18566933, DOI: 10.1682/jrrd.2007.03.0049.Peer-Reviewed Original ResearchConceptsSpinal cord injuryPeripheral nervous systemCentral nervous systemCord injuryAxonal regenerationNervous systemTreatment of SCIContusive spinal cord injuryPotential of olfactoryPermanent neurological deficitsSpecialized glial cellsCell therapy approachesCell transplantation approachesOEC biologyAxonal lossNeurological deficitsCell-based therapiesFunctional outcomeGlial cellsClinical studiesComplex lesionsMedicine cliniciansMacrophage activationTransplantation approachesInhibitory molecules
2004
Autologous transplantation of expanded neural precursor cells into the demyelinated monkey spinal cord
Oka S, Honmou O, Akiyama Y, Sasaki M, Houkin K, Hashi K, Kocsis JD. Autologous transplantation of expanded neural precursor cells into the demyelinated monkey spinal cord. Brain Research 2004, 1030: 94-102. PMID: 15567341, DOI: 10.1016/j.brainres.2004.09.062.Peer-Reviewed Original ResearchConceptsNeural precursor cellsAutologous transplantationSpinal cordPrecursor cellsSubventricular zoneAdult primate brainMonkey spinal cordCentral nervous system axonsPresence of mitogensAdult nonhuman primatesNon-human primatesNeurological deficitsDemyelinated lesionsDorsal columnsIntraspinal injectionElectron microscopic examinationControl lesionsLesion sitePrimate brainPeripheral patternMyelinated axonsTransplantationLesionsNonhuman primatesCord