Intravenous infusion of mesenchymal stem cells for protection against brainstem infarction in a persistent basilar artery occlusion model in the adult rat.
Namioka A, Namioka T, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Onodera R, Suzuki J, Sasaki Y, Nagahama H, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells for protection against brainstem infarction in a persistent basilar artery occlusion model in the adult rat. Journal Of Neurosurgery 2018, 131: 1308-1316. PMID: 30485204, DOI: 10.3171/2018.4.jns173121.Peer-Reviewed Original ResearchBasilar artery occlusionIschemic lesion volumeInfused mesenchymal stem cellsIntravenous infusionMesenchymal stem cellsLesion volumeBrainstem infarctionMSC infusionFunctional recoveryIntravenous MSC infusionIschemic brainstem lesionsPosterior circulation strokeAcute stroke therapyArtery occlusion modelGroup 28 daysNylon monofilament sutureReliable animal modelMultiple behavioral testsStem cellsProximal BAArtery occlusionBrainstem lesionsPosterior circulationStroke therapyFunctional outcome