2021
Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia.
Takemura M, Sasaki M, Kataoka-Sasaki Y, Kiyose R, Nagahama H, Oka S, Ukai R, Yokoyama T, Kocsis J, Ueba T, Honmou O. Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia. Journal Of Neurosurgery 2021, 137: 402-411. PMID: 34861644, DOI: 10.3171/2021.8.jns21687.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionInduction of MCAOCorpus callosumMesenchymal stem cellsChronic phaseMotor functionRat modelWeek 8Vehicle groupInterhemispheric connectionsAdministration of MSCsChronic cerebral ischemia modelNeural connectionsChronic stroke modelCerebral artery occlusionChronic cerebral ischemiaIschemic lesion volumeLong-term disabilityGreater functional improvementCerebral ischemia modelEnhanced functional recoveryAnti-neurofilament antibodiesDiffusion tensorSingle systemic infusionStem cells
2018
Intravenous infusion of mesenchymal stem cells promotes functional recovery in a rat model of chronic cerebral infarction.
Namioka T, Namioka A, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Onodera R, Suzuki J, Sasaki Y, Nagahama H, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells promotes functional recovery in a rat model of chronic cerebral infarction. Journal Of Neurosurgery 2018, 131: 1289-1296. PMID: 30485210, DOI: 10.3171/2018.5.jns18140.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionCerebral infarctionIntravenous infusionMesenchymal stem cellsChronic phaseRat modelBone marrowBlood-brain barrier integrityCerebral artery occlusionVehicle-treated groupChronic cerebral infarctionPhase of strokeStem cellsAdult bone marrowArtery occlusionBBB leakageMotor recoveryFunctional recoveryIschemic volumeFunctional outcomeSystemic infusionBrain parenchymaFunctional improvementSystemic injectionClinical studies
2017
Elevated brain derived neurotrophic factor levels in plasma reflect in vivo functional viability of infused mesenchymal stem cells for stroke in rats.
Nakamura H, Sasaki Y, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Namioka T, Namioka A, Onodera R, Suzuki J, Nagahama H, Mikami T, Wanibuchi M, Kocsis JD, Honmou O. Elevated brain derived neurotrophic factor levels in plasma reflect in vivo functional viability of infused mesenchymal stem cells for stroke in rats. Journal Of Neurosurgical Sciences 2017, 63: 42-49. PMID: 28181779, DOI: 10.23736/s0390-5616.17.03989-3.Peer-Reviewed Original ResearchConceptsInfused mesenchymal stem cellsMiddle cerebral artery occlusionVivo functional viabilityBDNF levelsMSC infusionMesenchymal stem cellsMCAO inductionPlasma BDNFNeurotrophic factorLesion volumeMSC groupMiddle cerebral artery occlusion modelPermanent middle cerebral artery occlusionCerebral infarction rat modelBrain BDNF levelsElicit functional recoveryIntravenous MSC infusionLimb placement testNeurotrophic factor levelsPlasma BDNF levelsCerebral artery occlusionArtery occlusion modelRat stroke modelFunctional viabilityImmunosorbent assay analysesIntravenous infusion of mesenchymal stem cells inhibits intracranial hemorrhage after recombinant tissue plasminogen activator therapy for transient middle cerebral artery occlusion in rats.
Nakazaki M, Sasaki M, Kataoka-Sasaki Y, Oka S, Namioka T, Namioka A, Onodera R, Suzuki J, Sasaki Y, Nagahama H, Mikami T, Wanibuchi M, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells inhibits intracranial hemorrhage after recombinant tissue plasminogen activator therapy for transient middle cerebral artery occlusion in rats. Journal Of Neurosurgery 2017, 127: 917-926. PMID: 28059661, DOI: 10.3171/2016.8.jns16240.Peer-Reviewed Original ResearchConceptsTransient middle cerebral artery occlusionRecombinant tissue plasminogen activatorMiddle cerebral artery occlusionRegional cerebral blood flowCerebral artery occlusionMesenchymal stem cellsHemorrhagic eventsArtery occlusionEndothelial dysfunctionRtPA therapyIntracerebral hemorrhageIntravenous infusionIncidence rateNormal salineIntravenous recombinant tissue plasminogen activatorRecombinant tissue plasminogen activator therapyTissue plasminogen activator therapyInfused mesenchymal stem cellsMatrix metalloproteinase-9 levelsEarly behavioral recoveryNon-rtPA groupAcute ischemic strokeVascular endothelial dysfunctionExperimental stroke modelsMetalloproteinase-9 levels
2016
Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats
Sasaki Y, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Suzuki J, Tateyama D, Oka S, Namioka T, Namioka A, Onodera R, Mikami T, Wanibuchi M, Kakizawa M, Ishiai S, Kocsis JD, Honmou O. Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats. Physical Therapy 2016, 96: 1791-1798. PMID: 27174259, DOI: 10.2522/ptj.20150504.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery occlusionIntravenous infusionDaily rehabilitationMesenchymal stem cellsMSC infusionFunctional outcomePermanent middle cerebral artery occlusionLimb placement testCerebral artery occlusionRat stroke modelRat MCAO modelIntraluminal vascular occlusionMagnetic resonance imagingStem cellsAdult bone marrowArtery occlusionCerebral ischemiaMCAO modelVascular occlusionFunctional improvementLesion volumeTherapy groupTherapeutic effectStroke modelGroup 2