2019
Prevention of neointimal hyperplasia induced by an endovascular stent via intravenous infusion of mesenchymal stem cells.
Nakazaki M, Oka S, Sasaki M, Kataoka-Sasaki Y, Onodera R, Komatsu K, Iihoshi S, Hiroura M, Kawaguchi A, Kocsis JD, Honmou O. Prevention of neointimal hyperplasia induced by an endovascular stent via intravenous infusion of mesenchymal stem cells. Journal Of Neurosurgery 2019, 133: 1773-1785. PMID: 31585431, DOI: 10.3171/2019.7.jns19575.Peer-Reviewed Original ResearchSuperficial cervical arteryCommon carotid arteryMarrow-derived mesenchymal stem cellsIntravenous infusionNeointimal hyperplasiaIschemic eventsInflammatory responseStent restenosisStent strutsMesenchymal stem cellsPorcine modelHuman middle cerebral arteryEndovascular stentsCerebral ischemic eventsPercutaneous transluminal angioplastyMiddle cerebral arteryBare metal stentsBone marrow-derived mesenchymal stem cellsDeployment of stentsStem cellsAngiographic imagesIntravascular ultrasound imagingTransluminal angioplastyCerebral arteryCerebral stroke
2011
Development of a Middle Cerebral Artery Occlusion Model in the Nonhuman Primate and a Safety Study of I.V. Infusion of Human Mesenchymal Stem Cells
Sasaki M, Honmou O, Radtke C, Kocsis JD. Development of a Middle Cerebral Artery Occlusion Model in the Nonhuman Primate and a Safety Study of I.V. Infusion of Human Mesenchymal Stem Cells. PLOS ONE 2011, 6: e26577. PMID: 22039510, PMCID: PMC3200343, DOI: 10.1371/journal.pone.0026577.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryMagnetic resonance imagingM1 occlusionCollateral circulationSevere groupVenous bloodOcclusion modelMesenchymal stem cellsMiddle cerebral artery occlusion modelM1 branchNHP stroke modelsExtensive collateral circulationArtery occlusion modelPost-operative courseMCA territory infarctionGreater functional improvementLeft sylvian fissureNonhuman primate modelFronto-temporal craniotomyExperimental stroke researchAfrican green monkeysStem cellsHMSC infusionTerritory infarctionNeurological examination