2014
Possible neural plasticity detected by fMRI associates with improved motor function following intravenous injection of mesenchymal stem cells in a rat stroke model
Nakazaki M, Suzuki J, Sasaki M, Oka S, Sasaki Y, Honmou O. Possible neural plasticity detected by fMRI associates with improved motor function following intravenous injection of mesenchymal stem cells in a rat stroke model. Cerebral Blood Flow And Metabolism (Japanese Journal Of Cerebral Blood Flow And Metabolism) 2014, 25: 67. DOI: 10.16977/cbfm.25.2_67.Peer-Reviewed Original ResearchFunctional recoveryMesenchymal stem cellsLesion volumeSensorimotor cortexMotor functionInfused groupIschemic stroke model ratsStroke model ratsGreater functional recoveryImproved motor functionImproved functional outcomesAutologous mesenchymal stem cellsRat stroke modelRandomized-clinical trialFMRI patternsStem cellsCerebral infarctionStroke patientsFunctional outcomeIntravenous transplantationModel ratsMSCs groupFunctional deficitsSomatosensory cortexClinical trials
2012
Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model
Suzuki J, Sasaki M, Harada K, Bando M, Kataoka Y, Onodera R, Mikami T, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O. Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model. Brain Research 2012, 1497: 15-22. PMID: 23274536, DOI: 10.1016/j.brainres.2012.12.028.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain InfarctionCerebral CortexDisease Models, AnimalExercise TestImage Processing, Computer-AssistedInfarction, Middle Cerebral ArteryMagnetic Resonance ImagingMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMovement DisordersOxygenRatsRats, Sprague-DawleyStatistics, NonparametricTime FactorsConceptsMSC groupMesenchymal stem cellsLesion volumeFunctional MRISensorimotor cortexMotor functionElectrical stimulationRat cerebral infarction modelGreater functional recoveryCerebral infarction modelImproved motor functionImproved functional outcomesRat stroke modelHigh-intensity signalStem cellsFunctional recoveryBilateral signalsCortical hyperactivityFunctional outcomeIntravenous infusionIntravenous transplantationFunctional deficitsSomatosensory cortexInfused groupStroke model