Detection of vulnerable neurons damaged by environmental insults in utero
Torii M, Sasaki M, Chang YW, Ishii S, Waxman SG, Kocsis JD, Rakic P, Hashimoto-Torii K. Detection of vulnerable neurons damaged by environmental insults in utero. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 2367-2372. PMID: 28123061, PMCID: PMC5338500, DOI: 10.1073/pnas.1620641114.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexElectroporationEmbryo, MammalianEthanolFemaleFlow CytometryGene Expression RegulationGenes, ReporterHeat Shock Transcription FactorsHeat-Shock ResponseLuminescent ProteinsMiceMice, TransgenicNeuronsNicotinePlasmidsPregnancyPrenatal Exposure Delayed EffectsResponse ElementsSuraminConceptsTransgenic reporter miceHeat shock factor 1 (HSF1) activationPrenatal exposureVulnerable neuronsPrognostic biomarkerReporter miceSusceptible individualsPostnatal disordersPostnatal lifeMultiple disordersNeuronsReporter assaysCellular damageEnvironmental insultsMiceHarmful agentsDisordersExposureTreatmentPhysical agentsFluorescence reporter systemPathogenesisSymptomsUteroAgents