Prevention of neointimal hyperplasia induced by an endovascular stent via intravenous infusion of mesenchymal stem cells.
Nakazaki M, Oka S, Sasaki M, Kataoka-Sasaki Y, Onodera R, Komatsu K, Iihoshi S, Hiroura M, Kawaguchi A, Kocsis JD, Honmou O. Prevention of neointimal hyperplasia induced by an endovascular stent via intravenous infusion of mesenchymal stem cells. Journal Of Neurosurgery 2019, 133: 1773-1785. PMID: 31585431, DOI: 10.3171/2019.7.jns19575.Peer-Reviewed Original ResearchSuperficial cervical arteryCommon carotid arteryMarrow-derived mesenchymal stem cellsIntravenous infusionNeointimal hyperplasiaIschemic eventsInflammatory responseStent restenosisStent strutsMesenchymal stem cellsPorcine modelHuman middle cerebral arteryEndovascular stentsCerebral ischemic eventsPercutaneous transluminal angioplastyMiddle cerebral arteryBare metal stentsBone marrow-derived mesenchymal stem cellsDeployment of stentsStem cellsAngiographic imagesIntravascular ultrasound imagingTransluminal angioplastyCerebral arteryCerebral stroke