2008
Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injury
Radtke C, Sasaki M, Lankford KL, Vogt PM, Kocsis JD. Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injury. The Journal Of Rehabilitation Research And Development 2008, 45: 141-152. PMID: 18566933, DOI: 10.1682/jrrd.2007.03.0049.Peer-Reviewed Original ResearchConceptsSpinal cord injuryPeripheral nervous systemCentral nervous systemCord injuryAxonal regenerationNervous systemTreatment of SCIContusive spinal cord injuryPotential of olfactoryPermanent neurological deficitsSpecialized glial cellsCell therapy approachesCell transplantation approachesOEC biologyAxonal lossNeurological deficitsCell-based therapiesFunctional outcomeGlial cellsClinical studiesComplex lesionsMedicine cliniciansMacrophage activationTransplantation approachesInhibitory moleculesOlfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X‐irradiated spinal cord not shared by Schwann cells
Lankford KL, Sasaki M, Radtke C, Kocsis JD. Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X‐irradiated spinal cord not shared by Schwann cells. Glia 2008, 56: 1664-1678. PMID: 18551623, DOI: 10.1002/glia.20718.Peer-Reviewed Original ResearchConceptsCentral nervous systemSpinal cordSchwann cellsOligodendrocyte progenitor cellsNormal central nervous systemMigratory propertiesOX-42 stainingNormal spinal cordOlfactory Ensheathing CellsMyelin-forming cellsDemyelinated lesionsHost axonsPhagocytic phenotypePoor survivalSubsequent lesionsNervous systemWhite matterCordLimited survivalOECsMigratory capabilityProgenitor cellsTransplantationX-irradiationLesions
2005
28 Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons
Kocsis J, Sasaki M. 28 Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons. 2005, 421-433. DOI: 10.1016/b978-012738761-1/50029-8.Peer-Reviewed Original ResearchTransplantation of SCsTransplantation of OECsSpinal cord injuryCentral nervous systemSchwann cellsAxonal regenerationBone marrow cellsFunctional recoveryMultiple sclerosisCell transplantationCord injurySpinal cordHind limb locomotor functionContusive spinal cord injuryBone marrow cell transplantationMarrow cellsSpinal cord injury modelMarrow cell transplantationCerebral ischemia modelSpinal cord resultsGlobal neuroprotectionDemyelination modelCord resultsFunctional outcomeDemyelinated axons