Aromatase-Inhibitor-Induced Musculoskeletal Inflammation Is Observed Independent of Oophorectomy in a Novel Mouse Model
Young N, Hampton J, Sharma J, Jablonski K, DeVries C, Bratasz A, Wu L, Lustberg M, Reinbolt R, Jarjour W. Aromatase-Inhibitor-Induced Musculoskeletal Inflammation Is Observed Independent of Oophorectomy in a Novel Mouse Model. Pharmaceuticals 2022, 15: 1578. PMID: 36559029, PMCID: PMC9785754, DOI: 10.3390/ph15121578.Peer-Reviewed Original ResearchAI treatmentFemale BALB/cHalf of patientsPositive breast cancerPro-inflammatory cytokines analysisFuture interventional strategiesNovel mouse modelBALB/cPhysiological estrogen levelsNovel animal modelMusculoskeletal inflammationSerum cytokinesEstrogen deficiencyCytokine analysisEstrogen combinationEstrogen levelsEstrogen productionAromatase inhibitorsBreast cancerHuman PBMCsInterventional strategiesMouse modelAnimal modelsNFκB activationBioluminescent imaging