2022
Point-of-care ultrasound for tuberculosis management in Sub-Saharan Africa—a balanced SWOT analysis
Suttels V, Du Toit J, Fiogbé A, Wachinou A, Guendehou B, Alovokpinhou F, Toukoui P, Hada A, Sefou F, Vinasse P, Makpemikpa G, Capo-Chichi D, Garcia E, Brahier T, Keitel K, Ouattara K, Cissoko Y, Beye S, Mans P, Agodokpessi G, Boillat-Blanco N, Hartley M. Point-of-care ultrasound for tuberculosis management in Sub-Saharan Africa—a balanced SWOT analysis. International Journal Of Infectious Diseases 2022, 123: 46-51. PMID: 35811083, DOI: 10.1016/j.ijid.2022.07.009.Peer-Reviewed Original ResearchConceptsTB managementCare ultrasoundLimitations of POCUSAdvent of ultrasoundLack of visualizationSub-Saharan AfricaTB contactTB sequelaePleural effusionLung pathologySubpleural nodulesHealthcare workersPericardial punctureTriage toolTuberculosis managementTB detectionMobile health devicesPoor specificityPOCUSUltrasoundTuberculosisObjective assessmentSmall consolidationsOperator dependencyRelevant literature
2020
Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study
Hartley M, Hofmann N, Keitel K, Kagoro F, Moniz C, Mlaganile T, Samaka J, Masimba J, Said Z, Temba H, Gonzalez I, Felger I, Genton B, D’Acremont V. Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study. PLOS Medicine 2020, 17: e1003318. PMID: 32956354, PMCID: PMC7505590, DOI: 10.1371/journal.pmed.1003318.Peer-Reviewed Original ResearchConceptsFebrile childrenLD patientsSecondary hospitalizationCohort studyLD infectionLow-density Plasmodium infectionsMalaria rapid diagnostic testsFebrile pediatric outpatientsPlasmodium falciparum parasitemiaPrimary care levelClinical decision support algorithmPrimary care facilitiesRapid diagnostic testsHigh-density infectionsViral originPediatric outpatientsUndifferentiated feverClinical featuresClinical presentationHD patientsSevere malnutritionClinical benefitIncidental findingPlasmodium infectionPolymerase chain reaction
2019
Detection of dicistroviruses RNA in blood of febrile Tanzanian children
Cordey S, Laubscher F, Hartley M, Junier T, Pérez-Rodriguez F, Keitel K, Vieille G, Samaka J, Mlaganile T, Kagoro F, Boillat-Blanco N, Mbarack Z, Docquier M, Brito F, Eibach D, May J, Sothmann P, Aldrich C, Lusingu J, Tapparel C, D’Acremont V, Kaiser L. Detection of dicistroviruses RNA in blood of febrile Tanzanian children. Emerging Microbes & Infections 2019, 8: 613-623. PMID: 30999808, PMCID: PMC6493270, DOI: 10.1080/22221751.2019.1603791.Peer-Reviewed Original ResearchConceptsTanzanian childrenViral RNA copies/Paediatric outpatient consultationsRNA copies/Higher positivity rateReal-time RT-PCRQuantitative real-time RT-PCRTanzanian adultsFebrile episodesViral loadOutpatient consultationsPositivity rateCopies/Causative pathogenNew agentsRT-PCRPlasma samplesFull-length genomeSusceptible populationChildrenViral originFurther investigationBloodSerumCapsid region
2017
Predicting Ebola Severity: A Clinical Prioritization Score for Ebola Virus Disease
Hartley M, Young A, Tran A, Okoni-Williams H, Suma M, Mancuso B, Al-Dikhari A, Faouzi M. Predicting Ebola Severity: A Clinical Prioritization Score for Ebola Virus Disease. PLOS Neglected Tropical Diseases 2017, 11: e0005265. PMID: 28151955, PMCID: PMC5289426, DOI: 10.1371/journal.pntd.0005265.Peer-Reviewed Original ResearchConceptsEbola virus diseaseViral loadPrognostic toolEbola viral loadMultivariate prognostic scoreRetrospective cohort studyEbola treatment centersAccurate prognostic toolVirus diseaseEVD mortalityClinical characteristicsCohort studyPrognostic scoreAsymptomatic infectionClinical severityIntensive treatmentPrognostic potentialUnadjusted predictorsDisease scoreMortality rateTreatment centersEVD diagnosisMortality risk reductionDeadly infectionEarly reportingExacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid
Castiglioni P, Hartley M, Rossi M, Prevel F, Desponds C, Utzschneider D, Eren R, Zangger H, Brunner L, Collin N, Zehn D, Kuhlmann F, Beverley S, Fasel N, Ronet C. Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid. PLOS Neglected Tropical Diseases 2017, 11: e0005240. PMID: 28099431, PMCID: PMC5242429, DOI: 10.1371/journal.pntd.0005240.Peer-Reviewed Original ResearchConceptsSymptomatic relapseVaccinated miceVaccine strategiesPotent innate immunogenSimilar viral infectionsVirus-related complicationsT-cell transferSpecific T cellsPoor treatment responseLesional inflammationSerum transferT helperInitial treatmentC57BL/6 miceNaïve miceLeishmania infectionPreventive benefitsVaccine opportunitiesT cellsTreatment responseImmune responseViral infectionLesion sizeClinical effortsLeishmania guyanensis
2016
Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus
Parmentier L, Cusini A, Müller N, Zangger H, Hartley M, Desponds C, Castiglioni P, Dubach P, Ronet C, Beverley S, Fasel N. Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus. American Journal Of Tropical Medicine And Hygiene 2016, 94: 840-843. PMID: 26834198, PMCID: PMC4824227, DOI: 10.4269/ajtmh.15-0803.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusLeishmania infectionCutaneous leishmaniasisPresence of LRV1Primary skin lesionsDrug treatment failureAggressive pathogenesisAntiretroviral therapyHIV patientsSpecies of LeishmaniaMurine leishmaniasisTreatment failureImmunodeficiency virusNasal lesionsRisk factorsEmergence of leishmaniasisSkin lesionsCutaneous afflictionsFurther exacerbationDisease severityLeishmania parasitesLeishmaniasisLeishmania braziliensisLRV1Patients
2015
Presence of Leishmania RNA Virus 1 in Leishmania guyanensis Increases the Risk of First-Line Treatment Failure and Symptomatic Relapse
Bourreau E, Ginouves M, Prévot G, Hartley M, Gangneux J, Robert-Gangneux F, Dufour J, Sainte-Marie D, Bertolotti A, Pratlong F, Martin R, Schütz F, Couppié P, Fasel N, Ronet C. Presence of Leishmania RNA Virus 1 in Leishmania guyanensis Increases the Risk of First-Line Treatment Failure and Symptomatic Relapse. The Journal Of Infectious Diseases 2015, 213: 105-111. PMID: 26123564, DOI: 10.1093/infdis/jiv355.Peer-Reviewed Original ResearchConceptsL. guyanensis infectionLeishmania RNA virus 1American tegumentary leishmaniasisSymptomatic relapseTreatment failureTegumentary leishmaniasisFirst-line treatment failureDoses of pentamidineLeishmania guyanensis infectionLine treatment failureFirst-line treatmentChronic cutaneous leishmaniasisVirus 1Second-line drugsExperimental murine leishmaniasisInflammatory markersHyperinflammatory responseExtended therapyMurine leishmaniasisTherapeutic choiceSuch complicationsRNA virus 1Persistent infectionCutaneous leishmaniasisRelapse