2017
Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid
Castiglioni P, Hartley M, Rossi M, Prevel F, Desponds C, Utzschneider D, Eren R, Zangger H, Brunner L, Collin N, Zehn D, Kuhlmann F, Beverley S, Fasel N, Ronet C. Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid. PLOS Neglected Tropical Diseases 2017, 11: e0005240. PMID: 28099431, PMCID: PMC5242429, DOI: 10.1371/journal.pntd.0005240.Peer-Reviewed Original ResearchConceptsSymptomatic relapseVaccinated miceVaccine strategiesPotent innate immunogenSimilar viral infectionsVirus-related complicationsT-cell transferSpecific T cellsPoor treatment responseLesional inflammationSerum transferT helperInitial treatmentC57BL/6 miceNaïve miceLeishmania infectionPreventive benefitsVaccine opportunitiesT cellsTreatment responseImmune responseViral infectionLesion sizeClinical effortsLeishmania guyanensis
2012
Leishmania RNA virus: when the host pays the toll
Hartley M, Ronet C, Zangger H, Beverley S, Fasel N. Leishmania RNA virus: when the host pays the toll. Frontiers In Cellular And Infection Microbiology 2012, 2: 99. PMID: 22919688, PMCID: PMC3417650, DOI: 10.3389/fcimb.2012.00099.Peer-Reviewed Original ResearchConceptsToll-like receptor 3Mucocutaneous leishmaniasisHyper-inflammatory immune responseLeishmania parasitesPotent innate immunogenExperimental animal modelsType 1 interferonLeishmania RNA virusAnti-leishmanial drugsMetastatic leishmaniasisDestructive inflammationMetastatic complicationsMetastatic diseaseInflammatory cascadeInflammatory stateRNA virusesSecondary lesionsImmune responseAnimal modelsClinical isolatesDisease severityReceptor 3Leishmania guyanensisMetastatic factorsClinical interventions